Results 101 to 110 of about 3,206,320 (297)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From "System Modeling" to "Controller Hardware Testing" in Three Hours: A Robotic Arm Controller Design Lab Using MATLAB Real Time Windows Target to Reinforce Classical Control Theory [PDF]

2015 ASEE Annual Conference and Exposition Proceedings, 2015
From system modeling to controller hardware testing in three hours: arobotic arm controller design lab using MATLAB Real Time Windows Target to reinforce classical control theoryA 3 hour hands-on lab experience was designed to give students the opportunity tomodel, design and test a controller for a nonlinear electro-mechanical robot-arm systemas a ...
openaire   +2 more sources

Robust nonlinear control of vectored thrust aircraft [PDF]

An interdisciplinary program in robust control for nonlinear systems with applications to a variety of engineering problems is outlined. Major emphasis will be placed on flight control, with both experimental and analytical studies.
Doyle, John C., Morris, John, Murray, Richard   +2 more
core   +1 more source

Adaptive and Supertwisting Adaptive Spacecraft Orbit Control Around Asteroids

, 2019
This paper addresses the development of control systems for the orbit control of spacecraft around irregularly shaped rotating asteroids with uncertain parameters. The objective is to steer the spacecraft along prescribed orbits.
Lee, Keum W., Singh, Sahjendra N.
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Access control oriented quantified trust degree representation model for distributed systems

Tongxin xuebao, 2010
Based on the research fruit of social trust in sociology,the semantics,properties and elements of trust in the context of access control of distributed systems were defined.By combining fuzzy set theory with probability theory,a mathematical definition ...
LANG Bo
doaj   +2 more sources

An Adaptive Task Difficulty Model for Personalized Reading Comprehension in AI-Based Learning Systems

Algorithms
This article proposes an interpretable adaptive control model for dynamically regulating task difficulty in Artificial intelligence (AI)-augmented reading-comprehension learning systems.
Aray M. Kassenkhan, Mateus Mendes, Akbayan Bekarystankyzy   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source