Results 91 to 100 of about 3,206,320 (297)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Fuzzy Predictive Fault-Tolerant Control for Time-Delay Nonlinear Systems with Partial Actuator Failures

Complexity, 2019
A fuzzy predictive fault-tolerant control (FPFTC) scheme is proposed for a wide class of discrete-time nonlinear systems with uncertainties, interval time-varying delays, and partial actuator failures as well as unknown disturbances, in which the main ...
Huiyuan Shi, Ping Li, Chengli Su, Jingxian Yu   +3 more
doaj   +1 more source

Infrared Laser Driven Double Proton Transfer. An Optimal Control Theory Study

, 2009
Laser control of ultrafast double proton transfer is investigated for a two-dimensional model system describing stepwise and concerted transfer pathways.
Balzani, Beck, Brixner, Combariza, de Vivie-Riedle, Došlić, Došlić, Došlić, Geva, Gräfe, Jakubetz, Korolkov, Kühn, Lopez del Amo, Mahmoud K. Abdel-Latif, May, Meyer, Mitrić, Naundorf, Nishikawa, Oliver Kühn, Peirce, Rabitz, Rice, Schröder, Shapiro, Smedarchina, Smedarchina, Smedarchina, Sundermann, Thanopulos, Thanopulos, Uiberacker, Waluk, Wang, Werschnik, Wohlleben, Zhu   +37 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Model-Based Development of Control Systems for Forestry Cranes

Journal of Control Science and Engineering, 2015
Model-based methods are used in industry for prototyping concepts based on mathematical models. With our forest industry partners, we have established a model-based workflow for rapid development of motion control systems for forestry cranes.
Pedro La Hera, Daniel Ortíz Morales
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Finite-Time Stability and Stabilization of Networked Control Systems with Bounded Markovian Packet Dropout

Discrete Dynamics in Nature and Society, 2014
The finite-time stability and stabilization problems of a class of networked control systems (NCSs) with bounded Markovian packet dropout are investigated.
Yeguo Sun, Guanjun Li
doaj   +1 more source

Methods to Classify, Forewarn and Pre-control Routine Operation in Hazardous Liquid Chemical Storage and Transportation Port

Chemical Engineering Transactions, 2017
In light of the actual operation and risk characteristics of hazardous liquid chemical storage and transportation port, we identified the division of eight types of routine operations in this paper.
Zhu Zeng, Gongzhong Wang
doaj   +1 more source

Duality and Network Theory in Passivity-based Cooperative Control

, 2013
This paper presents a class of passivity-based cooperative control problems that have an explicit connection to convex network optimization problems. The new notion of maximal equilibrium independent passivity is introduced and it is shown that networks ...
Allgöwer, Frank, Bürger, Mathias, Zelazo, Daniel   +2 more
core   +1 more source