Results 71 to 80 of about 3,206,320 (297)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

On the Origins and Applications of the Cybernetic Steady-State Model as Systems-Theoretical Reference Model

Systems
Few publications have elaborated on the steady-state model, a ‘cybernetic model’ that should not be confused with its namesake in mathematical systems; it is rooted in preceding publications about general systems theories, something that is explored in ...
Rob Dekkers
doaj   +1 more source

Sensitivity of the Game Control of Ship in Collision Situations

Polish Maritime Research, 2015
The paper introduces the application of the theory of deterministic sensitivity control systems for sensitivity analysis taking place in game control systems of moving objects, such as ships.
Lisowski Józef
doaj   +1 more source

The Responsibility Quantification (ResQu) Model of Human Interaction with Automation

, 2020
Intelligent systems and advanced automation are involved in information collection and evaluation, in decision-making and in the implementation of chosen actions. In such systems, human responsibility becomes equivocal.
Douer, Nir, Meyer, Joachim
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Generic Modeling and Control Framework for Power Systems Dominated by Power Converters Connected Through a Passive Transmission and Distribution Grid

CSEE Journal of Power and Energy Systems
In this paper, a compact mathematical model having an elegant structure, together with a generic control framework, are proposed for generic power systems dominated by power converters that are interconnected through a passive transmission and ...
Qing-Chang Zhong, Marcio Stefanello
doaj   +1 more source

Adaptive event-triggered control for new type tyre systems based on vehicles

Systems Science & Control Engineering, 2021
In this article, an adaptive event-triggered control scheme is first investigated for new type tyre systems based on vehicle. The intricate systems are transformed into a nonlinear model to research.
Ruitong Wu, Kewen Li
doaj   +1 more source

Decentralized Convergence to Nash Equilibria in Constrained Deterministic Mean Field Control

, 2015
This paper considers decentralized control and optimization methodologies for large populations of systems, consisting of several agents with different individual behaviors, constraints and interests, and affected by the aggregate behavior of the overall
Colombino, Marcello, Grammatico, Sergio, Lygeros, John, Parise, Francesca   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source