Results 61 to 70 of about 351,249 (309)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of fuzzy logic in modeling, identification and control [PDF]

Modeling, Identification and Control, 1994
In the nearly four decades which have passed since the launching of the Sputnik, great progress has been achieved in our understanding of how to model, identify and control complex systems.
Lotfi A. Zadeh
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Stability Analysis and Design of Time-Varying Nonlinear Systems Based on Impulsive Fuzzy Model

Discrete Dynamics in Nature and Society, 2012
This paper develops a general analysis and design theory for nonlinear time-varying systems represented by impulsive T-S fuzzy control model, which extends conventional T-S fuzzy model.
Yuangan Wang, Honglin Yu, Xiaohong Zhang, Dong Li   +3 more
doaj   +1 more source

A Study on Influencing Factors of Knowledge Management Systems Adoption: Models Comparison Approach [PDF]

Journal of Library and Information Studies, 2007
Using Linear Structural Relation model (LISREL model) as analysis method and technology acceptance model and decomposed theory of planned behavior as research foundation, this study approaches mainly from the angle of behavioral intention to examine the ...
Mei-Chun Yeh, Ming-Shu Yuan
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

On the Origins and Applications of the Cybernetic Steady-State Model as Systems-Theoretical Reference Model

Systems
Few publications have elaborated on the steady-state model, a ‘cybernetic model’ that should not be confused with its namesake in mathematical systems; it is rooted in preceding publications about general systems theories, something that is explored in ...
Rob Dekkers
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Generic Modeling and Control Framework for Power Systems Dominated by Power Converters Connected Through a Passive Transmission and Distribution Grid

CSEE Journal of Power and Energy Systems
In this paper, a compact mathematical model having an elegant structure, together with a generic control framework, are proposed for generic power systems dominated by power converters that are interconnected through a passive transmission and ...
Qing-Chang Zhong, Marcio Stefanello
doaj   +1 more source