Results 151 to 160 of about 11,900,338 (247)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Shaking table model test and numerical analysis of the steeply dipping bedded rock slopes under seismic actions. [PDF]

Sci Rep
Wang C, Zhang P, Dong J, Meng L, Li L, Li M.   +5 more
europepmc   +1 more source

Model test study on the effect of dynamic compaction under low water content. [PDF]

PLoS One, 2021
Zhang X, Wang M, Han Y.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Using physical model test and numerical simulation for revealing the mechanism of stope collapse: a case study. [PDF]

Sci Rep
Zhang R, Xie C, Chen J.
europepmc   +1 more source

[Model test study on treatment of Pruzansky type ⅡB and Ⅲ hemifacial microsomia with artificial condyle-mandibular distractor complex]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2023
Zhao R, Fu X, Qiao J, He Y, Xu S, Chen Y, Yu B, Liu J, Niu F.   +8 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparative analysis and verification on broken rock zone of model test based on multiple testing methods. [PDF]

Sci Rep
Liu G, Liu Z, Luan Y, Xian J.
europepmc   +1 more source

Laboratory model test study of the hydrological effect on granite residual soil slopes considering different vegetation types. [PDF]

Sci Rep, 2021
Chen J, Lei XW, Zhang HL, Lin Z, Wang H, Hu W.   +5 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source