Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Model test study on the effect of dynamic compaction under low water content. [PDF]
Zhang X, Wang M, Han Y.
europepmc +1 more source
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Using physical model test and numerical simulation for revealing the mechanism of stope collapse: a case study. [PDF]
Zhang R, Xie C, Chen J.
europepmc +1 more source
[Model test study on treatment of Pruzansky type ⅡB and Ⅲ hemifacial microsomia with artificial condyle-mandibular distractor complex]. [PDF]
Zhao R +8 more
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Comparative analysis and verification on broken rock zone of model test based on multiple testing methods. [PDF]
Liu G, Liu Z, Luan Y, Xian J.
europepmc +1 more source
Laboratory model test study of the hydrological effect on granite residual soil slopes considering different vegetation types. [PDF]
Chen J +5 more
europepmc +1 more source
Simulation of Model Force-Loading with Changing Its Position in the Wind Tunnel Test Section
В. Т. Буй, А. И. Хлупнов
openalex +1 more source

