Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
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Dvelopment and application of similar material for physical model test of an ultradeep foundation pit in round gravel strata. [PDF]
Guo Y +9 more
europepmc +1 more source
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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Bearing Characteristics of Screw-Groove Piles: Model Test and Numerical Analysis. [PDF]
Zhao H, Deng Y, Zhuang Z, Yao Z.
europepmc +1 more source
The Characterization Pattern of Overburden Deformation with Distributed Optical Fiber Sensing: An Analogue Model Test and Extensional Analysis. [PDF]
Yuan Q, Chai J, Ren Y, Liu Y.
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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A structural equation model test of affect, family warmth, and substance use among American Indian reservation-based adolescents. [PDF]
Swaim RC, Crabtree MA, Egli MR.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
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Study on the Ratio and Model Test of Similar Materials of Heavily Weathered Granite. [PDF]
Hu G, Song W, Yu X, Lin M, Tie Y, He B.
europepmc +1 more source
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source

