Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Factors Associated with the Intention to Adopt Digital Health Technologies for Physical Activity Among People with Disabilities: An Integrated Technology Acceptance Model-Theory of Planned Behavior Framework. [PDF]
Healthcare (Basel)Park J, Lee H, Kwon Y, Cho G, Yun J.
europepmc +1 more source
Kumaraswamy log-logistic Weibull distribution: model, theory and application to lifetime and survival data. [PDF]
Heliyon, 2019 Mdlongwa P +4 more
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, 2008 In this paper we emphasize the links between model theory and tilings. More precisely, after giving the definitions of what tilings are, we give a natural way to have an interpretation of the tiling rules in first order logics. This opens the way to map some model theoretical properties onto some properties of sets of tilings, or tilings themselves.
Ballier, Alexis, Jeandel, Emmanuel
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Drug-Use Safety Enhancement Model-Theory and Application. [PDF]
Public Health ChallDunbar ET, Bartkowiak A, Brennan AL.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Marine Propulsors and Current Turbines: State of the Art and Current Challenges
International Journal of Rotating Machinery, 2012 Yin Lu Young +4 more
doaj +1 more source
A New Approach for Estimating Liver IVIM Fast Diffusion Coefficient in Two-Compartment Model and Fast Diffusion Fraction in Three-Compartment Model: Theory and In Vivo Validation of Two Centers' Data. [PDF]
NMR BiomedMa FZ, Wáng YXJ.
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