Results 101 to 110 of about 7,715,827 (290)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Computer-animated model of accommodation and theory of reciprocal zonular action

open access: yesClinical Ophthalmology, 2011
Daniel B Goldberg1,2 1Ophthalmology Department, Drexel College of Medicine, Philadelphia, PA, 2Eye Physicians, Little Silver, NJ, USA Abstract: This report presents a computer-animated model of the structures of accommodation based on new understanding ...
Goldberg DB
doaj  

Model theory of modules

open access: yesAnnals of Pure and Applied Logic, 1984
This paper was a break-through, both in methods and in results. Exemplifying the strong correlation between model theory and algebra in the context of modules, it had great impetus on further developments of not only model theoretic, but also purely algebraic nature, as well as on those where both aspects overlap essentially (cf. e.g.
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Theory of planned behavior and smoking: meta-analysis and SEM model

open access: yesSubstance Abuse and Rehabilitation, 2010
Gabriela Topa, Juan Antonio MorianoDepartment of Social and Organizational Psychology, UNED, Madrid, SpainAbstract: To examine if the theory of planned behavior (TPB) predicts smoking behavior, 35 data sets (N = 267,977) have been synthesized, containing
Gabriela Topa, Juan Antonio Moriano
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

On λ strong homogeneity existence for cofinality logic

open access: yesCubo, 2011
Let C Reg be a non-empty class (of regular cardinals). Then the logic has additional nice properties: it has the homogeneous model existence property.Sea C Reg una clase no vacía (de cardinales regulares). Entonces la lógica tiene propiedades adicionales:
Saharon Shelah
doaj  

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