Results 61 to 70 of about 1,021,911 (264)

A Model Theory of Topology

open access: yesStudia Logica
An algebraization of the notion of topology has been proposed more than seventy years ago in a classical paper by McKinsey and Tarski. However, in McKinsey and Tarski's setting the model theoretical notion of homomorphism does not correspond to the notion of continuity.
openaire   +4 more sources

MODEL THEORY AND ULTRAPRODUCTS [PDF]

open access: yesProceedings of the International Congress of Mathematicians (ICM 2018), 2019
The article motivates recent work on saturation of ultrapowers from a general mathematical point of view.
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Contextual measurement model and quantum theory

open access: yesRoyal Society Open Science
We develop a contextual measurement model (CMM) that is used for the clarification of the quantum foundations. This model matches Bohr’s views on the role of experimental contexts.
Andrei Khrennikov
doaj   +1 more source

Central types of convex fragments of the perfect Jonsson theory

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2019
In this paper, the central types of convex fragments of the perfect Jonsson theory are considered. The main goal of this paper is to redefine the A.D.
A.R. Yeshkeyev, M.T. Omarova
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The “Academic Literacies” Model: Theory and Applications

open access: yesFilologia e Linguística Portuguesa, 2014
Although the term academic literacies was originally developed with regard to the study of literacies in higher education and the university, the concept also applies to K–12 education.
Fabiana Cristina Komesu   +1 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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