Results 41 to 50 of about 1,346,290 (248)

Impact of Soil Moisture Data Assimilation on Analysis and Medium-Range Forecasts in an Operational Global Data Assimilation and Prediction System

Atmosphere, 2021
Accurate initial soil moisture conditions are essential for numerical weather prediction models, because they play a major role in land–atmosphere interactions.
Sanghee Jun, Jeong-Hyun Park, Hyun-Joo Choi, Yong-Hee Lee, Yoon-Jin Lim, Kyung-On Boo, Hyun-Suk Kang   +6 more
doaj   +1 more source

Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R. Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A. Barkauskas, Rajkumar Venkatramani, Sheri L. Spunt, Aaron R. Weiss, Noah C. Federman   +11 more
wiley   +1 more source

A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions

CPT: Pharmacometrics & Systems Pharmacology, 2021
The success of applications of physiologically‐based pharmacokinetic (PBPK) modeling in drug development and drug labeling has triggered regulatory agencies to demand rigorous demonstration of the predictive capability of the specific PBPK platform for a
Sebastian Frechen, Juri Solodenko, Thomas Wendl, André Dallmann, Ibrahim Ince, Thorsten Lehr, Jörg Lippert, Rolf Burghaus   +7 more
doaj   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

Study on neighborhood ensemble probability forecasting method of precipitation for CMA-REPS system

暴雨灾害, 2023
In this paper, based on the regional ensemble CMA-REPS V3.1 system, the algorithm for the neighborhood ensemble probability method of precipitation is optimized.
Zhili LIU, Jing CHEN, Fajing CHEN, Jingzhuo WANG   +3 more
doaj   +1 more source

Network Models

Theory and Applications of Categories, 2020
Networks can be combined in various ways, such as overlaying one on top of another or setting two side by side. We introduce "network models" to encode these ways of combining networks. Different network models describe different kinds of networks.
Baez, John C, Foley, John, Moeller, Joe, Pollard, Blake S   +3 more
openaire   +4 more sources

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Creation of the spacecraft’s command-and-measurement system’s heterogeneous simulation model

Космические аппараты и технологии, 2020
This article presents software tools designed for construction of heterogeneous models by software integration of logical models having their work methods set in the knowledge bases and engineering models created in a technical simulation environment. In
O. S. Isaeva, L. F. Nozhenkova, A. V. Mishurov, A. N. Kamyshnikov, V. V. Evstratko, A. S. Chernigovskiy   +5 more
doaj   +1 more source

The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Scientific Reports, 2022
SARS-CoV-2 is the pathogen responsible for COVID-19 that has claimed over six million lives as of July 2022. The severity of COVID-19 motivates a need to understand how it could evolve to escape potential treatments and to find ways to strengthen ...
Jonathan E. Barnes, Peik K. Lund-Andersen, Jagdish Suresh Patel, F. Marty Ytreberg   +3 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source