Results 51 to 60 of about 12,063,985 (329)
Distributed agent-based building evacuation simulator [PDF]
, 2012 The optimisation of the evacuation of a building plays a fundamental role in emergency situations. The behaviour of individuals, the directions that civilians receive, and the actions of the emergency personnel, will affect the success of the operation ...
Filippoupolitis, Avgoustinos +6 more
core
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Frontiers in Artificial Intelligence, 2023 Modeling has actively tried to take the human out of the loop, originally for objectivity and recently also for automation. We argue that an unnecessary side effect has been that modeling workflows and machine learning pipelines have become restricted to only well-specified problems.
Mustafa Mert Çelikok +3 more
openaire +5 more sources
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Proceedings, MSVSCC 2015 [PDF]
, 2015 The Virginia Modeling, Analysis and Simulation Center (VMASC) of Old Dominion University hosted the 2015 Modeling, Simulation, & Visualization Student capstone Conference on April 16th. The Capstone Conference features students in Modeling and Simulation,
Old Dominion University, Department of Modeling, Simulation & Visualization Engineering +1 more
core +1 more source
Model Risk of Risk Models [PDF]
SSRN Electronic Journal, 2014 This paper evaluates the model risk of models used for forecasting systemic and market risk. Model risk, which is the potential for different models to provide inconsistent outcomes, is shown to be increasing with and caused by market uncertainty. During calm periods, the underlying risk forecast models produce similar risk readings, hence, model risk ...
Danielsson, Jon +3 more
openaire +5 more sources
Creation of the spacecraft’s command-and-measurement system’s heterogeneous simulation model
Космические аппараты и технологии, 2020 This article presents software tools designed for construction of heterogeneous models by software integration of logical models having their work methods set in the knowledge bases and engineering models created in a technical simulation environment. In
O. S. Isaeva +5 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2021 The success of applications of physiologically‐based pharmacokinetic (PBPK) modeling in drug development and drug labeling has triggered regulatory agencies to demand rigorous demonstration of the predictive capability of the specific PBPK platform for a
Sebastian Frechen +7 more
doaj +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Non-model model organisms [PDF]
BMC Biology, 2017 Model organisms are widely used in research as accessible and convenient systems to study a particular area or question in biology. Traditionally only a handful of organisms have been widely studied, but modern research tools are enabling researchers to extend the set of model organisms to include less-studied and more unusual systems.
Madeline A. Lancaster +20 more
openaire +6 more sources