Results 51 to 60 of about 7,875,864 (298)
CPT: Pharmacometrics & Systems Pharmacology, 2021 The success of applications of physiologically‐based pharmacokinetic (PBPK) modeling in drug development and drug labeling has triggered regulatory agencies to demand rigorous demonstration of the predictive capability of the specific PBPK platform for a
Sebastian Frechen +7 more
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Ecological Questions, 2008 When searching for nature rules we encounter a fundamental difficulty: for technical reasons we are not able to investigate the whole Nature - we have to explore its sections i.e. empirical systems (structures). However, even then it might happen that the system is too complex and its comprehensive, direct investigation is impossible.
openaire +3 more sources
Nature CommunicationsThe intricate hydrogen-bonded network of water gives rise to various structures with anomalous properties at different thermodynamic conditions. Nanoconfinement can further modify the water structure and properties, and induce specific water motifs ...
Aran Lamaire +5 more
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CMA Global Ensemble Prediction Using Singular Vectors from Background Field
应用气象学报, 2022 China Meteorological Administration Global Ensemble Prediction System (CMA-GEPS) adopts singular vector method to generate initial perturbations.
Huo Zhenhua +3 more
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Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
A RBA model for the chemostat modeling [PDF]
2019 IEEE 58th Conference on Decision and Control (CDC), 2019 Extended version of conference paper to appear in Conference on Decision and Control ...
Dinh, Marc, Fromion, Vincent
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Scientific Reports, 2022 SARS-CoV-2 is the pathogen responsible for COVID-19 that has claimed over six million lives as of July 2022. The severity of COVID-19 motivates a need to understand how it could evolve to escape potential treatments and to find ways to strengthen ...
Jonathan E. Barnes +3 more
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