Results 61 to 70 of about 1,346,290 (248)

Modeling model selection in model pluralism [PDF]

Journal of Economic Methodology, 2018
ABSTRACTIn his recent book, Rodrik [(2015). Economics rules. Why economics works, when it fails, and how to tell the difference. Oxford University Press] proposes an account of model pluralism according to which multiple models of the same target are acceptable as long as one model is more useful for one purpose and another is more useful for another ...
Marchionni Caterina, Grune-Yanoff Till
openaire   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Application of Heuristic Methods for Polymer Synthesis Process Optimization

Journal of Engineering
A numerical algorithm has been developed for solving the problem of finding optimal conditions for the synthesis of polymers using heuristic optimization methods, and its effectiveness has been evaluated in the investigation of the copolymerization ...
Eldar Miftakhov, Svetlana Mustafina, Andrey Akimov   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Extended MHD modeling of the steady solar corona and the solar wind

Living Reviews in Solar Physics, 2018
The history and present state of large-scale magnetohydrodynamic modeling of the solar corona and the solar wind with steady or quasi-steady coronal physics is reviewed.
Tamas I. Gombosi, Bart van der Holst, Ward B. Manchester, Igor V. Sokolov   +3 more
doaj   +1 more source

Models. Models. Models. So What? [PDF]

, 2009
In 1985, in an interview for some then-popular magazine, I was asked when models and model-driven development would become commonplace. "In three years time", I replied confidently. In 1987, I was asked the same question, and my answer remained the same. And 1989. And '91.
openaire   +1 more source

Computational modelling [PDF]

Current Opinion in Neurobiology, 1994
Computation modelling is playing an increasingly accepted and important role in neuroscience. It is not a unitary enterprise, though, and the distinction between two different sorts of modelling, one interested in description and the other also in function, is illustrated by their application to activity-dependent developmental plasticity and adult ...
openaire   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A Mathematical Model of Suspension Filtration With Formation of a Consolidated Sediment

Journal of Applied Mathematics
A model for suspension filtration in a porous medium is developed with the formation of a consolidating sediment. A system of equations including the equation for determining the pressure and the equations for determining the saturation of the medium by ...
Bakhtiyor Kh. Khuzhayorov, Jamol M. Makhmudov, K. K. Viswanathan, Otabek U. Nazarov, Tulkin I. Begmatov   +4 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source