Results 201 to 210 of about 425,473 (267)

Next-Generation Artificial Intelligence Strategies for Mechanistic Cancer Target Discovery and Drug Development: A State-of-the-Art Review. [PDF]

Int J Mol Sci
Khan MS, Saeed M, Arham M, Zafar I, Hussian M, Jamal A, Usman M, Bahwerth FS, Yang G, Kang KS.   +9 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Intelligent therapeutic robotic-assisted surgery as the next frontier of precision oncology. [PDF]

Front Oncol
Satyam SM, Wali AF, El-Tanani M, Sarfraz A, Khalil I, Alghoul WI, Bhat AA, Mansor I, Alhammadi MA, Al-Shammari WBJ, Nasser RAS, Menon A, Alahmad OM.   +12 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Adaptive cruise control for electric vehicles using hybrid-mode MPC. [PDF]

Sci Rep
Sharkawy AE, Ali AM, Asfoor MS, Yacoub MI.   +3 more
europepmc   +1 more source

Integrating biomarkers and artificial intelligence for precision diagnostics in cattle health and herd management: a review. [PDF]

Vet Res Commun
Aydın Ş, Özdemir S.
europepmc   +1 more source

Synergistic Intensification of Bioactive Compounds in Germinated Brown Rice via Ultrasonic-Enzymatic Pretreatment: Multi-Objective Modeling Using RSM, ANN-GA, and ANN-PSO. [PDF]

ACS Omega
Chamsai T, Wongwilad K, Wanyo P.
europepmc   +1 more source

Multiscale Modeling of Quantum Dot Solar Cells: Integration of Density Functional Theory, SCAPS, Lambert W Analysis, and Machine Learning. [PDF]

ACS Omega
Yahyaoui N.
europepmc   +1 more source

Quantitative Systems Pharmacology Modeling Amid the Rise of Agentic AI. [PDF]

CPT Pharmacometrics Syst Pharmacol
Lu J, Desikan R.
europepmc   +1 more source

Advanced persistent threat detection through multi-modal behavioral analysis. [PDF]

PLoS One
Alshamrani A.
europepmc   +1 more source