Results 81 to 90 of about 603,423 (297)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Computational aerothermodynamics [PDF]
Computational aerothermodynamics (CAT) has in the past contributed to the understanding of real-gas flows encountered by hypervelocity reentry vehicles. With advances in computational fluid dynamics, in the modeling of high temperature phenomena, and in ...
Deiwert, George S., Green, Michael J.
core +1 more source
Modeling and Robust Attitude Controller Design for a Small Size Helicopter
, 2018 This paper addresses the design and application controller for a small-size unmanned aerial vehicle (UAV). In this work, the main objective is to study the modeling and attitude controller design for a small size helicopter.
He, Jilin, He, Miaolei
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Pleasure, Imagination, Fear and Joy: Applied Themes in Nicole Oresme’s de Configurationibus [PDF]
Memoirs of the Scientific Sections of the Romanian Academy, 2018 The present work explores the idea that concepts present in Nicole Oresme’s work, and rooted in the medieval revival of Corpus Aristotelicum, are reflected throughout active areas of research today.
Isabel M. Serrano +2 more
doaj
Experiments with metallic and ceramic porous media [PDF]
Work in the area of mechano-caloric phenomena was initiated during 1988 with startup in the Summer 1988 period. The ideal system utilizing He-II super-phenomena is modeled readily, within the frame of thermodynamics energetics, using the concept of an ...
Abbassi, P. +3 more
core +1 more source
Evolving Spatially Aggregated Features from Satellite Imagery for Regional Modeling
, 2017 Satellite imagery and remote sensing provide explanatory variables at relatively high resolutions for modeling geospatial phenomena, yet regional summaries are often desirable for analysis and actionable insight.
AE Hoerl +15 more
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Budownictwo o Zoptymalizowanym Potencjale EnergetycznymThe article investigates the potential application of CAD systems for predicting the mechanical properties of structural materials by comparing experimental test results with data from nonlinear simulations.
Olena Gumen +3 more
doaj +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source