Results 61 to 70 of about 8,065,895 (294)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Systematic review of multiscale thermal prediction models for FDM/FFF additive manufacturing: Toward digital twin integration with physics-informed machine learning

Results in Engineering
Fused filament fabrication/fused deposition modeling (FFF/FDM) is a widely used additive manufacturing (AM) technique valued for its affordability, safety, and greater accessibility compared to metal-based AM processes.
Dame Alemayehu Efa, Dejene Alemayehu Ifa
doaj   +1 more source

BRANCHING PROCESS MODELLING: A TOOL FOR DECIPHERING COMPLEX REAL-WORLD PHENOMENA USING R PROGRAMMING

FUDMA JOURNAL OF SCIENCES, 2023
The reproduction of organisms such as human beings, cells or neutrons can be modeled via branching processes.The theory of branching processes offers suitable mathematical models to depict the chance-based progression of systems, where elements like cells, particles, or general individuals replicate and perish over a certain lifespan.
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Towards a Model-Driven Engineering Approach for Developing Embedded Hard Real-Time Software

, 2008
Model-Driven Engineering (MDE) has been advocated as an effective way to deal with today's software complexity. MDE can be seen as an integrative approach combining existing techniques such as Domain-Specific Modeling Languages (DSML) and Transformation ...
Cordeiro, Lucas, Maciel, Paulo, Cruz, Fabiano, Barreto, Raimundo, Cordeiro, Lucas; id_orcid   +4 more
core   +1 more source

Matching of an observed event and its virtual model in relation to smart theories, coupled models and supervision of complex procedures—A review

Comptes Rendus. Physique
This contribution aims to illustrate the nature of the observation–modeling (or real–virtual) link, the importance of the exact model (or coupled model) in the matching involved in this link and the use of this link in the supervision of complex ...
Razek, Adel
doaj   +1 more source

Pedestrian simulation: Theoretical models vs. data driven techniques

International Journal of Transportation Science and Technology, 2018
This paper presents a comparison and relative assessment of data driven techniques and conventional theoretical pedestrian simulation models. Data driven methods are applied for simulating phenomena without a priori knowledge of parameter connections ...
George Kouskoulis, Ioanna Spyropoulou, Constantinos Antoniou   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Modeling and Simulation in Engineering Design and Technology: Improving Project/Product Performance

International Journal of Technology, 2014
The use of modeling and simulation (M&S) to increase project or product performance within engineering design and technology is well recognized. The reasons for increasing the use of modeling and simulation applications include the ability to simulate ...
Mohammed Ali Berawi
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source