Results 81 to 90 of about 2,549,734 (331)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Matching of an observed event and its virtual model in relation to smart theories, coupled models and supervision of complex procedures—A review

Comptes Rendus. Physique
This contribution aims to illustrate the nature of the observation–modeling (or real–virtual) link, the importance of the exact model (or coupled model) in the matching involved in this link and the use of this link in the supervision of complex ...
Razek, Adel
doaj   +1 more source

Pedestrian simulation: Theoretical models vs. data driven techniques

International Journal of Transportation Science and Technology, 2018
This paper presents a comparison and relative assessment of data driven techniques and conventional theoretical pedestrian simulation models. Data driven methods are applied for simulating phenomena without a priori knowledge of parameter connections ...
George Kouskoulis, Ioanna Spyropoulou, Constantinos Antoniou   +2 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Modeling and Simulation in Engineering Design and Technology: Improving Project/Product Performance

International Journal of Technology, 2014
The use of modeling and simulation (M&S) to increase project or product performance within engineering design and technology is well recognized. The reasons for increasing the use of modeling and simulation applications include the ability to simulate ...
Mohammed Ali Berawi
doaj   +1 more source

Experiments with metallic and ceramic porous media [PDF]

Work in the area of mechano-caloric phenomena was initiated during 1988 with startup in the Summer 1988 period. The ideal system utilizing He-II super-phenomena is modeled readily, within the frame of thermodynamics energetics, using the concept of an ...
Abbassi, P., Frederking, T. H. K., Khandhar, P. K., Luna, Jack   +3 more
core   +1 more source

Scientific Inference with Interpretable Machine Learning: Analyzing Models to Learn About Real-World Phenomena

Minds and Machines
AbstractTo learn about real world phenomena, scientists have traditionally used models with clearly interpretable elements. However, modern machine learning (ML) models, while powerful predictors, lack this direct elementwise interpretability (e.g. neural network weights).
Timo Freiesleben, Gunnar König, Christoph Molnar, Álvaro Tejero-Cantero   +3 more
openaire   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Experimental validation of the model approach in professional psychological selection of law enforcement officers

Психология и право, 2018
This article discusses the problems of modeling personality-suitability of employees of internal affairs agencies (staff) in the psychology of performance. The model is presented as an activity centred construct. Subject of study modeled in stages in the
Kubyshko V.L., Kruk V.M., Noss I.N., Borodina T.I.   +3 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source