Results 131 to 140 of about 28,765,428 (344)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A web oriented function-based volume modeling framework

, 2008
The paper presents a web-oriented function-based modeling framework utilizing a high-level volume modeling language for defining 3D point sets and their volumetric attributes.
Fryazinov, Oleg, Stamm, Cherie, Vilbrandt, Turlif, Pasko, Alexander   +3 more
core  

Z-Score of Modeling Tools.

, 2013
Z-Score of Modeling Tools.
Grace A. Maresh (293454), David Worthylake (293452), Louis LeCour Jr (293453), Seth H. Pincus (293455), Zhiyu Zhao (293451)   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Tools and Methods for RTCP-Nets Modeling and Verification

Archives of Control Sciences, 2016
RTCP-nets are high level Petri nets similar to timed colored Petri nets, but with different time model and some structural restrictions. The paper deals with practical aspects of using RTCP-nets for modeling and verification of real-time systems.
Szpyrka Marcin, Biernacki Jerzy, Biernacka Agnieszka   +2 more
doaj   +1 more source

Supporting Focus and Context Awareness in 3D Modeling Using Multi-Layered Displays

, 2013
Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years.
Mohd Yusof, Azmi
core  

The Role of Measurement and Modelling of Machine Tools in Improving Product Quality

, 2013
Manufacturing of high-quality components and assemblies is clearly recognised by industrialised nations as an important means of wealth generation. A “right first time” paradigm to producing finished components is the desirable goal to maximise economic ...
Parkinson, Simon, Fletcher S., Parkinson, S., Fletcher, Simon, S. Fletcher, Fletcher, S., Myers, Alan, Longstaff, Andrew P., Myers, A., Myers A., Longstaff, A. P., S. Parkinson, Parkinson S., Longstaff A.P., A.P. Longstaff, A. Myers   +15 more
core   +1 more source

Hammering Models: Designing Usable Modeling Tools

, 2011
Part 1: Long and Short PapersInternational audienceA modeling tool not only helps users express their ideas and thoughts but also serves as a communication platform among domain experts, designers, developers, and others practitioners.
Leonel Nobrega, Nunes, Nuno,, Constantine, Larry, Nuno Jardim Nunes, Monchu Chen, Ko-Hsun Huang, Huang, Ko-Hsun, Nobrega, Leonel, Larry Constantine, Chen, Monchu   +9 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source