Results 261 to 270 of about 27,648,855 (348)

Understanding the mechanisms of TAVI durability through computational modelling: a multidisciplinary review. [PDF]

Eur Heart J Digit Health
Rauseo E, Bevis L, Chen X, Petersen SE, Mathur A, Slabaugh GG, Roney CH.   +6 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Models of Models of Models of Models of Things

, 2017
openaire   +1 more source

One Health antimicrobial resistance modelling: from science to policy. [PDF]

Sci One Health
Redman-White CJ, Knight G, Lanzas C, Mader R, Bunnik BV, Mardones FO, Muwonge A, Lhermie G, Peters AR, Moran D.   +9 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Health workforce planning methods in rural and remote primary care: a scoping review. [PDF]

Hum Resour Health
Argus G, Gavaghan B, Spinks J.
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

A conceptual health economic modelling framework to assess the cost-effectiveness of molecular target-driven treatment regimens in oncology. [PDF]

Acta Oncol
Frisell O, Aas E, Henkel PS, Fagereng GL, Taskén K, Hallersjö Hult E, Lindgren P, Steen Carlsson K.   +7 more
europepmc   +1 more source

Simulation-based assessment of a Bayesian M-spline survival model with flexible baseline hazard and time-dependent effects. [PDF]

BMC Med Res Methodol
Timmins IR, Torabi F, Jackson CH, Lambert PC, Sweeting MJ.   +4 more
europepmc   +1 more source

Improving Children's Diets by Introducing Fruits and Vegetables in Group-Based Settings: A Scoping Review. [PDF]

Nutr Rev
Pickard A, Alving-Jessep E, Delivett C, Jenkins RH, Pullar L, Farrow C, Blissett J.   +6 more
europepmc   +1 more source