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SFlex-WMS: a novel multi-expert system for flexible logistics and warehouse operation in the context of Industry 4.0 [PDF]

open access: yesSHS Web of Conferences, 2021
Production lines form the backbone of a manufacturing plant while the warehouse is the heart that pumps the supplies through logistics veins. However, logistics issues among manufacturing industries are well known for causing downstream production ...
Ng Sokchoo   +3 more
doaj   +1 more source

Ecohydraulics Modelling and Simulation [PDF]

open access: yesWater, 2021
Ecohydraulics, the interdiscipline of ecology and hydraulics, has been rapidly developing and receiving ever-growing attention both in hydraulic research efforts and in environmentally oriented professional and lay communities in recent years [...]
openaire   +2 more sources

Concept and application of the probability of pharmacological success (PoPS) as a decision tool in drug development: a position paper

open access: yesJournal of Translational Medicine, 2023
Background In drug development, few molecules from a large pool of early candidates become successful medicines after demonstrating a favourable benefit-risk ratio.
Chao Chen   +4 more
doaj   +1 more source

The area under the effect curve as an efficacy determinant for anti‐infectives

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2022
Pharmacokinetic/pharmacodynamic (PK/PD) indices making use of area under the curve, maximum concentration, and the duration that in vivo drug concentration is maintained above a critical level are commonly applied to clinical dose prediction from animal ...
Chao Chen   +2 more
doaj   +1 more source

‘Falling heads’: investigating reflexive responses to head–neck perturbations

open access: yesBioMedical Engineering OnLine, 2022
Background Reflexive responses to head–neck perturbations affect the injury risk in many different situations ranging from sports-related impact to car accident scenarios.
Isabell Wochner   +3 more
doaj   +1 more source

An investigation of tendon strains in jersey finger injury load cases using a finite element neuromuscular human body model

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Introduction: A common hand injury in American football, rugby and basketball is the so-called jersey finger injury (JFI), in which an eccentric overextension of the distal interphalangeal joint leads to an avulsion of the connected musculus flexor ...
Lennart V. Nölle   +4 more
doaj   +1 more source

A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity

open access: yesPharmacology Research & Perspectives, 2022
Treatment response to clopidogrel is associated with CYP2C19 activity through the formation of the active H4 metabolite. The aims of this study were to develop a physiologically based pharmacokinetic (PBPK) model of clopidogrel and its metabolites for ...
Janna K. Duong   +4 more
doaj   +1 more source

Contrail Modeling and Simulation [PDF]

open access: yesAnnual Review of Fluid Mechanics, 2016
There is large uncertainty in the radiative forcing induced by aircraft contrails, particularly after they transform to cirrus. It has recently become possible to simulate contrail evolution for long periods after their formation. We review the main physical processes and simulation efforts in the four phases of contrail evolution, namely the jet ...
Roberto Paoli, Karim Shariff
openaire   +1 more source

Modelling opinion dynamics under the impact of influencer and media strategies

open access: yesScientific Reports, 2023
Digital communication has made the public discourse considerably more complex, and new actors and strategies have emerged as a result of this seismic shift.
Luzie Helfmann   +3 more
doaj   +1 more source

Self-Organization Dynamics of Collagen-like Peptides Crosslinking Is Driven by Rose-Bengal-Mediated Electrostatic Bridges

open access: yesPharmaceutics, 2022
The present work focuses on the computational study of the structural micro-organization of hydrogels based on collagen-like peptides (CLPs) in complex with Rose Bengal (RB).
Roberto Rosales-Rojas   +5 more
doaj   +1 more source

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