Results 41 to 50 of about 1,154,864 (307)

Analytic and numerical realisations of a disk galaxy [PDF]

, 2010
Recent focus on the importance of cold, unshocked gas accretion in galaxy formation -- not explicitly included in semi-analytic studies -- motivates the following detailed comparison between two inherently different modelling techniques: direct ...
A. J. Benson, A. M. Brooks, Agertz, Benson, Benson, Benson, Birnboim, Bower, Bower, Brooks, Brooks, Cattaneo, Cole, Croton, Dekel, Efstathiou, F. Governato, Gill, Governato, Governato, Governato, Haardt, Hatton, Helly, Häring, Jiang, Katz, Kauffmann, Kauffmann, Kennicutt, Kereš, Knollmann, Kroupa, Lacey, M. J. Stringer, Maiolino, Mayer, Moore, Ocvirk, Pontzen, Press, Quinn, Read, Sharma, Springel, Stinson, Stringer, Stringer, Sutherland, Tormen, Wadsley, White, Yoshida, Zolotov   +53 more
core   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Using multilevel random coefficient models to assess students’ spelling abilities [PDF]

, 2010
This paper presents statistical models that analyze cross- sectional data related to student attainment in English and Maltese spelling. For each spelling test a random sample of 2040 students, whose age ranged from 6.5 to 16 years, was selected to ...
Camilleri, Liberato, Firman, Christine, Martinelli, Victor, The European Simulation and Modelling Conference (ESM'2010), Ventura, Frank   +4 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The estimation and translation uncertainties in applying NOAEL to clinical dose escalation

Clinical and Translational Science
The systemic exposure at the no‐observed‐adverse‐effect‐level (NOAEL) estimated from animals is an important criterion commonly applied to guard the safety of participants in clinical trials of investigational drugs.
Chao Chen, Silvia Maria Lavezzi, David McDougall   +2 more
doaj   +1 more source

Visual Trajectory-Tracking Model-Based Control for Mobile Robots

International Journal of Advanced Robotic Systems, 2013
In this paper we present a visual-control algorithm for driving a mobile robot along the reference trajectory. The configuration of the system consists of a two-wheeled differentially driven mobile robot that is observed by an overhead camera, which can ...
Andrej Zdešar, Igor Škrjanc, Gregor Klančar   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Potential applications of simulation modelling techniques in healthcare: lessons learned from aerospace and military [PDF]

, 2008
The Aerospace and Military areas are to do with complex missions and situations. Modelling and Simulation (M&S) has been applied in many areas of defence ranging from space sciences, satellite engineering to multi-warfare (air warfare, undersea warfare),
Eldabi, T, Jahangirian, M, Stergioulas, LK   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Multi-objective stochastic simulation-based optimisation applied to supply chain planning

Technological and Economic Development of Economy, 2012
The paper discusses the optimisation of complex management processes, which allows the reduction of investment costs by setting the optimal balance between product demand and supply. The systematisation of existing methods and algorithms that are used to
Liana Napalkova, Galina Merkuryeva
doaj   +1 more source