Results 41 to 50 of about 109,654 (268)
Ecohydraulics Modelling and Simulation [PDF]
Water, 2021 Ecohydraulics, the interdiscipline of ecology and hydraulics, has been rapidly developing and receiving ever-growing attention both in hydraulic research efforts and in environmentally oriented professional and lay communities in recent years [...]
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Role of fragmentation in as-cast structure: numerical study and experimental validation [PDF]
China Foundry, 2017 A volume average solidification model is extended to incorporate fragmentation as the source of equiaxed crystals during mixed columnar-equiaxed solidification.
Yong-jian Zheng +2 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Simulation of econometric models [PDF]
Proceedings of the 6th conference on Winter simulation, 1973 The purposes of this tutorial are to present some fundamental properties of econometric model structures relevant to effective understanding of simulation procedures, and to describe the use of simulation software for analysis and forecasting.The fundamental concepts of model specification are developed formally to provide a logical foundation for ...
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Scientific ReportsThis paper focuses on the urgent issue of minimising the impact of pollutants on aquatic life in river ecosystems. Our innovative approach involves the integration of mathematical modelling and strategic control methods to counteract the negative ...
Marouane Karim +5 more
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Frontiers in EducationThis study examines the effectiveness of the Teaching at the Right Level (TaRL) program when enriched by the judicious use of Information and Communication Technologies for Education (ICTE), from an explicit teaching perspective.
Mounia Machkour +4 more
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