Results 51 to 60 of about 110,051 (268)

Mathematical modelling and control approach for sustainable ecosystems in mitigating the impact of pollutants on aquatic species in rivers

Scientific Reports
This paper focuses on the urgent issue of minimising the impact of pollutants on aquatic life in river ecosystems. Our innovative approach involves the integration of mathematical modelling and strategic control methods to counteract the negative ...
Marouane Karim, Imane Dehaj, Ali Akgül, Murad Khan Hassani, Hanane Ferjouchia, Mostafa Rachik   +5 more
doaj   +1 more source

Impact of using an educational robotics model on students’ innovation: the case of a final year class at a technical high school in Morocco

Frontiers in Education
The current Moroccan high school curriculum, especially in the final year class of the mechanical science and technology discipline, looks like it insufficiently promotes the development of interdisciplinary and practical skills.
Younes Zidani, Younes Zahrou, Salah Nissabouri, Moulay El Houssine Ech-Chhibat, Khalifa Mansouri   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A New Paradigm for Scientific Computing: Accelerated Algorithm Development With Large Reasoning Models

IEEE Access
This study examines the application of Large Reasoning Model (LRM)-based artificial intelligence (AI) agents to accelerate scientific discovery, with a specific focus on the rapid prototyping of numerical algorithms.
Ioannis W. Kokkinakis, Dimitris Drikakis
doaj   +1 more source

Coupled thermal and mechanical analysis of composite cross sections using mathematical optimization strategies

Engineering Structures and Technologies, 2017
In the present article an alternative approach for the coupled thermal and mechanical analysis of composite cross sections under temperature effects is introduced, which uses the mathematical optimization as a consistent methodical base.
Christopher Taube, Hans-Georg Timmler, Marcel Helmrich, Guido Morgenthal   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Synergy between explicit teaching, ICT integration, and the TaRL approach: structural modeling of learning gains

Frontiers in Education
This study examines the effectiveness of the Teaching at the Right Level (TaRL) program when enriched by the judicious use of Information and Communication Technologies for Education (ICTE), from an explicit teaching perspective.
Mounia Machkour, Hiba Gharbaoui, Latifa Lamalif, Sophia Faris, Khalifa Mansouri   +4 more
doaj   +1 more source

Shock Reduction through Opposing Jets—Aerodynamic Performance and Flight Stability Perspectives

Applied Sciences, 2019
In this research paper, investigations of counter flow (opposing) jet on the aerodynamic performance, and flight stability characteristics of an airfoil with blunt leading-edge in supersonic regime are performed. Unsteady Reynolds-Averaged Navier-Stokes (
Shagufta Rashid, Fahad Nawaz, Adnan Maqsood, Rizwan Riaz, Shuaib Salamat   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source