Results 51 to 60 of about 109,654 (268)
Engineering Structures and Technologies, 2017 In the present article an alternative approach for the coupled thermal and mechanical analysis of composite cross sections under temperature effects is introduced, which uses the mathematical optimization as a consistent methodical base.
Christopher Taube +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Modeling and simulation with INSIGHT [PDF]
Proceedings of the 18th conference on Winter simulation - WSC '86, 1986 The INSIGHT simulation language describes systems in a quick, simple, and compact fashion using a network representation. This description can be entered and simulated using novel interactive facilities that relieve the user of needing to know specific syntax, while promoting a greater understanding of model behavior.
openaire +1 more source
Contrail Modeling and Simulation [PDF]
Annual Review of Fluid Mechanics, 2016 There is large uncertainty in the radiative forcing induced by aircraft contrails, particularly after they transform to cirrus. It has recently become possible to simulate contrail evolution for long periods after their formation. We review the main physical processes and simulation efforts in the four phases of contrail evolution, namely the jet ...
Roberto Paoli, Karim Shariff
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IEEE AccessThis study examines the application of Large Reasoning Model (LRM)-based artificial intelligence (AI) agents to accelerate scientific discovery, with a specific focus on the rapid prototyping of numerical algorithms.
Ioannis W. Kokkinakis, Dimitris Drikakis
doaj +1 more source
Shock Reduction through Opposing Jets—Aerodynamic Performance and Flight Stability Perspectives
Applied Sciences, 2019 In this research paper, investigations of counter flow (opposing) jet on the aerodynamic performance, and flight stability characteristics of an airfoil with blunt leading-edge in supersonic regime are performed. Unsteady Reynolds-Averaged Navier-Stokes (
Shagufta Rashid +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
AlgorithmsThis paper appraises convolutional neural network (CNN) models’ capabilities in emotion detection from facial expressions, seeking to aid the diagnosis of psychosomatic illnesses, typically made in clinical setups.
Marta Narigina +2 more
doaj +1 more source