Results 51 to 60 of about 1,154,864 (307)
Frontiers in Oncology, 2022 This study seeks to investigate the interaction profile of the L5 protein of oncolytic adenovirus with the overexpressed surface receptors of pancreatic cancer.
Maryum Nisar +8 more
doaj +1 more source
Decision makers\u27 experience of participatory dynamic simulation modelling: Methods for public health policy [PDF]
, 2018 Background: Systems science methods such as dynamic simulation modelling are well suited to address questions about public health policy as they consider the complexity, context and dynamic nature of system-wide behaviours.
Atkinson, Jo-An +4 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Modelling iteration in engineering design [PDF]
, 2007 This paper examines design iteration and its modelling in the simulation of New Product Development (NPD) processes. A framework comprising six perspectives of iteration is proposed and it is argued that the importance of each perspective depends upon ...
Clarkson, PJ, Eckert, CM, Wynn, DC
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Modelling and simulation of a quad-rotor helicopter [PDF]
, 2012 Small size quad-rotor helicopters are often used due to the simplicity of their construction and maintenance, their ability to hover and also to take-off and land vertically.
Bousbaine, Amar +2 more
core +2 more sources
Ecohydraulics Modelling and Simulation [PDF]
Water, 2021 Ecohydraulics, the interdiscipline of ecology and hydraulics, has been rapidly developing and receiving ever-growing attention both in hydraulic research efforts and in environmentally oriented professional and lay communities in recent years [...]
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Role of fragmentation in as-cast structure: numerical study and experimental validation [PDF]
China Foundry, 2017 A volume average solidification model is extended to incorporate fragmentation as the source of equiaxed crystals during mixed columnar-equiaxed solidification.
Yong-jian Zheng +2 more
doaj +1 more source