Results 141 to 150 of about 7,167,330 (247)

The cosmological model of eternal inflation and the transition from chance to biological evolution in the history of life: The possibility of chance emergence of the replication and translation systems, and the protein superfolds

, 2007
Eugene V. Koonin
openalex   +2 more sources

Modeling and simulating crowdsourcing as a complex biological system: human crowds manifesting collective intelligence on the internet [PDF]

, 2011

openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

DigiLoCS: A leap forward in predictive organ-on-chip simulations. [PDF]

PLoS One
Aravindakshan MR, Mandal C, Pothen A, Schaller S, Maass C.   +4 more
europepmc   +1 more source

Modelling biological complexity: a physical scientist's perspective

Journal of the Royal Society Interface, 2005
P. Coveney, P. Fowler
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Energy-based analysis of biochemical oscillators using bond graphs and linear control theory. [PDF]

R Soc Open Sci
Gawthrop P, Pan M.
europepmc   +1 more source

Biological and Biomechanical Evaluation of the Ligament Advanced Reinforcement System (LARS AC) in a Sheep Model of Anterior Cruciate Ligament Replacement: A 3-Month and 12-Month Study [PDF]

, 2013
Véronique Viateau, Mathieu Manassero, Fani Anagnostou, Sandra Guérard, David Mitton, Véronique Migonney   +5 more
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Dynamic modelling of signalling pathways when ordinary differential equations are not feasible. [PDF]

Bioinformatics
Rachel T, Brombacher E, Wöhrle S, Groß O, Kreutz C.   +4 more
europepmc   +1 more source