Results 191 to 200 of about 10,674,828 (317)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Integration of biological avatars and digital twins for "ex vivo clinical trials". [PDF]

EBioMedicine
Howe CL.
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Quantitative Systems Pharmacology (QSP): Bridging Biology and Mechanism with Clinical Drug Development Decisions. [PDF]

J Clin Pharmacol
Wang W, Ratushny AV, Chang S, Cheng Y, Gong JQX, Gulati A, Hansson E, Kulesza A, Reali F, Sandefur C, Schmidt BJ, Singh FA, Susilo ME, Zaph S, Shtylla B.   +14 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists. [PDF]

FASEB J
Athéa H, Heck N.
europepmc   +1 more source

Multiscale modeling on biological systems [PDF]

Biochemical and Biophysical Research Communications, 2018
Sulpizi, Marialore, Faller, Roland, Pantano, Sergio   +2 more
openaire   +4 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Relating transcriptomics to protein abundance reveals self-driven versus interactor-driven proteins. [PDF]

Protein Sci
Arnaout L, Helms V, Papazian A.
europepmc   +1 more source

MULTI-COMPARTMENTED BIOLOGIC MODELS [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1954
J B, STANBURY, G L, BROWNELL
openaire   +2 more sources