Results 241 to 250 of about 24,835,738 (277)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

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A biologic model of parasystole

The American Journal of Cardiology, 1979
The electrotonic interactions of a parasystolic pacemaker with ventricular responses to the normal pacemaker across an area of depressed excitability were simulated in a model consisting of strands of canine Purkinje fibers mounted in a sucrose gap preparation.
José Jalife, Gordon K. Moe
openaire   +3 more sources

Modeling of Biological Materials

2007
Preface Rheology of Living Materials / R. Chotard-Ghodsnia and C. Verdier Biochemical and Biomechanical Aspects of Blood Flow / M. Thiriet Theoretical Modeling of Enlarging Intracranial Aneurysms / S. Baeck, K.R. Rajagopal, and J.D. Humphrey Theoretical Modeling of Cyclically Loaded, Biodegradeable Cylinders / J.S. Soares, J.E.
MOLLICA, Francesco, PREZIOSI L, RAJAGOPAL K. R.   +2 more
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Models of biological systems and biological processes

Pure and Applied Chemistry, 1994
Abstract
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A model of biological indeterminacy

Journal of Theoretical Biology, 1972
Abstract It is a known mathematical fact that the introduction of statistical indeterminacy by means of quantum mechanics (including statistical mechanics) has not loosened up theoretical physics enough so that theoretical biologists could go essentially beyond reductionism. A different type of indeterminacy, designated biological, is introduced here,
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A mathematical model of biological evolution

Journal of Mathematical Biology, 1982
In order to understand generally how the biological evolution rate depends on relevant parameters such as mutation rate, intensity of selection pressure and its persistence time, the following mathematical model is proposed: dNn(t)/dt = (mn(t) - mu)Nn(t) + muNn-1(t) (n = 0,1,2,3,...), where Nn(t) and mn(t) are respectively the number and Malthusian ...
N. Ogita, Kazushige Ishii, Hirotsugu Matsuda   +2 more
openaire   +4 more sources

The development of largangians for biological models

Bulletin of Mathematical Biology, 1982
A modern theory of the calculus of variations is used to form necessary and sufficient conditions for the existence of a Lagrangian representation of a system of first-order ordinary differential equations. There exists a theorem to the effect that when a system of ordinary differential equations is variationally self-adjoint, the fulfillment of such ...
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The Biological Model

1983
“It’s a curious sensation, isn’t it? Really thrilling … but why? You know, I get the feeling—or rather I see it—as if the ball is made of elastic, as if it’s expanding into an ellipse … shall we say trying to free itself?”
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