Results 31 to 40 of about 24,835,738 (277)

New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2

Marine Drugs, 2021
Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), one ...
Peihai Li, Mengqi Zhang, Haonan Li, Rongchun Wang, Hairong Hou, Xiaobin Li, Kechun Liu, Hao Chen   +7 more
doaj   +1 more source

Setting Parameters for Biological Models With ANIMO [PDF]

, 2014
ANIMO (Analysis of Networks with Interactive MOdeling) is a software for modeling biological networks, such as e.g. signaling, metabolic or gene networks. An ANIMO model is essentially the sum of a network topology and a number of interaction parameters.
Karperien, Marcel, Langerak, Rom, Post, Janine N., Schivo, Stefano, Scholma, Jetse, van de Pol, Jaco   +5 more
core   +3 more sources

Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

Journal of Lipid Research, 2015
DHA is an important omega-3 PUFA that confers neurodevelopmental benefits. Sufficient omega-3 PUFA intake has been associated with improved mood-associated measures in adult humans and rodents, but it is unknown whether DHA specifically influences these ...
Michael J. Weiser, Kelly Wynalda, Norman Salem, Jr., Christopher M. Butt   +3 more
doaj   +1 more source

Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson’s disease

Pharmaceutical Biology, 2020
Context L-DOPA is the first-line drug for Parkinson’s disease (PD). However, chronic use can lead to dyskinesia. Caffeine, which is a known neuroprotectant, can potentially act as an adjunct to minimise adverse effects of L-DOPA.
Rafael Vincent M. Manalo, Paul Mark B. Medina   +1 more
doaj   +1 more source

The Effect of a Unique Region of Parvovirus B19 Capsid Protein VP1 on Endothelial Cells

Biomolecules, 2021
Parvovirus B19 (B19V) is a widespread human pathogen possessing a high tropism for erythroid precursor cells. However, the persistence or active replication of B19V in endothelial cells (EC) has been detected in diverse human pathologies.
Ieva Rinkūnaitė, Egidijus Šimoliūnas, Daiva Bironaitė, Rasa Rutkienė, Virginija Bukelskienė, Rolandas Meškys, Julius Bogomolovas   +6 more
doaj   +1 more source

Automatic landmarking for building biological shape models [PDF]

, 2002
We present a new method for automatic landmark extraction from the contours of biological specimens. Our ultimate goal is to enable automatic identification of biological specimens in photographs and drawings held in a database.
Bayer, M.M., Hicks, Y., Manning, D.G., Marshall, D., Martin, R.R., Rosin, P.L.   +5 more
core   +3 more sources

Melanins: Skin Pigments and Much More—Types, Structural Models, Biological Functions, and Formation Routes

, 2014
This review presents a general view of all types of melanin in all types of organisms. Melanin is frequently considered just an animal cutaneous pigment and is treated separately from similar fungal or bacterial pigments.
F. Solano
semanticscholar   +1 more source

On validation and invalidation of biological models [PDF]

BMC Bioinformatics, 2009
Very frequently the same biological system is described by several, sometimes competing mathematical models. This usually creates confusion around their validity, ie, which one is correct. However, this is unnecessary since validity of a model cannot be established; model validation is actually a misnomer.
Anderson, J, Papachristodoulou, A
openaire   +4 more sources

Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos

Frontiers in Pharmacology, 2021
Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from Aconitum plants, is widely used in traditional herbal medicine to treat various diseases.
Qing Xia, Qing Xia, Qing Xia, Shuo Gao, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Samuel Rajendran Rapael Gnanamuthu, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Kaiyan Zhuang, Kaiyan Zhuang, Zhenzhen Song, Zhenzhen Song, Zhenzhen Song, Yun Zhang, Yun Zhang, Yun Zhang, Xue Wang, Xue Wang, Xue Wang, Pengfei Tu, Pengfei Tu, Pengfei Tu, Jianheng Li, Kechun Liu, Kechun Liu, Kechun Liu   +26 more
doaj   +1 more source

Development and validation of computational models of cellular interaction [PDF]

, 2004
In this paper we take the view that computational models of biological systems should satisfy two conditions – they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be ...
Holcombe, W.M.L., Smallwood, R.H. [r.smallwood@shef.ac.uk], Walker, D.C.   +2 more
core   +1 more source