Results 181 to 190 of about 1,506,413 (213)

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect

Advanced Science, EarlyView.
Due to the synergistic effect of ENernst,H2O2${E}_{\mathrm{Nernst},\ {\mathrm{H}}_{2}{\mathrm{O}}_{2}}$ and ENernst,H+${E}_{\mathrm{Nernst},\ {\mathrm{H}}^{+}}$, the proposed sensors in this study can achieve ultralow H2O2 detection limit as low as 1.8 × 10−12 M based on the stacked PEDOT: BTB/PEDOT: PSS semiconducting layer.
Zhaoqun Wang, Wen Gao, Xiaorong Niu, Yuhang Liu, Zichen Jin, Fan Zhang, Zhengdong Cheng, Xiaoning Jiang, Wendong Zhang, Ting Wang, Jianlong Ji, Xiaojie Chai, Shengbo Sang   +12 more
wiley   +1 more source

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Modeling Cardiovascular Disease in the Zebrafish

Trends in Cardiovascular Medicine, 2008
The zebrafish possesses a host of advantages that have established it as an excellent model of vertebrate development. These include ease of genetic manipulation and transgenesis, optical clarity, and small size and cost. Biomedical researchers are increasingly exploiting these advantages to model human disease mechanisms. Here we review the use of the
Chico, Timothy J. A., Ingham, Philip W., Crossman, David C.   +2 more
openaire   +4 more sources

Examples of cardiovascular models

Journal of Chronic Diseases, 1966
RATIONALE OF CIRCULATORY MODELS In a recent symposium on computers in cardiovascular research, Dr. RUSHMER [2] made the following comments: “High-speed computers can accelerate progress by setting up current concepts as mathematical models*, testing their validity against the best available data and using the results to help determine what additional ...
openaire   +3 more sources

A Mathematical Model of the Cardiovascular System Based on the Scranton Cardiovascular Model

The FASEB Journal, 2016
The complexity of the cardiovascular system has led to the development of mathematical models to understand and predict physiological function and dysfunction. The unique model that we describe here is designed to match the Scranton Cardiovascular Model (SCM), a mechanical model that we recently developed1 to be used as a teaching tool.
Jason M. Graham, Norman E Frederick, Terrence Edward Sweeney, Joshua Ray N. Jimenez   +3 more
openaire   +2 more sources

Modeling in cardiovascular biomechanics

International Journal of Engineering Science, 2010
Abstract In this review, we briefly summarize some of Professor K.R. Rajagopal’s contributions to the field of cardiovascular mechanics and highlight some applications that have employed his theories and have expanded the ability to model the complex behaviors that characterize biological tissues.
David A. Vorp, João S. Soares, James E. Moore, Salvatore Pasta   +3 more
openaire   +2 more sources