Results 241 to 250 of about 8,258,117 (261)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Artificial Intelligence in Cardiovascular Ultrasound: Clinical Applications, Foundation Models, and the Path to Precision Cardiology. [PDF]

J Clin Med
Tupu AE, Tudor SS, Dumitru CN, Stefan CS, Ferțu ID.   +4 more
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

The Role of the KLF Family in T-Cell-Mediated Regulation of Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Prospects. [PDF]

Cells
Wang S, Zhu X, Li N, Ouyang K, Liao Z.
europepmc   +1 more source

Proteinase-Activated Receptor 2 (PAR2) Deficiency and Cardiovascular Regulation: Context-Dependent Effects on Inflammation and Fibrosis. [PDF]

Curr Issues Mol Biol
Viola SA, Siddiqua S, Adesuyi J, Jang Y, Ryskina M, McGuire JJ.   +5 more
europepmc   +1 more source

Resting Heart Rate Association with Cardiovascular Morbidity and Mortality and All-Cause Mortality According to Cluster of Cardiovascular Risk Factors-A Prospective Cohort Study with More than 20 Years of Follow-Up. [PDF]

J Clin Med
Carbayo-Herencia JA, Artigao Ródenas LM, Simarro-Rueda M, Molina-Escribano F, Navarro-Blazquez F, Gil-Guillén V, Banegas JR, Divisón Garrote JA.   +7 more
europepmc   +1 more source

Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health. [PDF]

Int J Mol Sci
Zainalabidin S, Ravindran G, Abdul Ghani MA, Azman AZ, Ping CY, Ahmad AA, Yusof NLM, Jubaidi FF.   +7 more
europepmc   +1 more source

Multichamber Myocardial Strain for Cardiovascular Risk Stratification in Liver Transplant Recipients Using Interpretable Machine Learning. [PDF]

JACC Adv
Park WD, Okeke B, Hobbs S, Manikandan S, Ahmed RS, Frey L, Agbim U, Benjamin MM, SLU Transplant Rx Group.   +8 more
europepmc   +1 more source

Predicting treatment-related cardiovascular risks in breast cancer patients: development and validation of an interpretable machine learning model. [PDF]

Front Oncol
Wang L, Yan R, Zhu X, Yu J, Cui F.
europepmc   +1 more source