Results 221 to 230 of about 2,739,180 (294)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Data curation in cheminformatics: importance and implementation. [PDF]

J Cheminform
Esaki T, Ikeda K.
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Rapid discrimination of geographical origin and analysis of chemical characterization of tobacco leaves from multiple countries. [PDF]

Front Chem
Kou R, Wang C, Wan R, Su M, Xu H, Fu Y, Lin Y, Song X, Bi Y, Zhao L, Guo J, Wang H, Liu Z, Yang S, Nie C.   +14 more
europepmc   +1 more source

Structural optimization of drug molecules with incrementally trained language models. [PDF]

Nat Commun
Hörmann T, Mayer D, Lewandowski M, Hunklinger A, Wein T, Merk D.   +5 more
europepmc   +1 more source

Combined computational and classical medicinal chemistry procedure to disclose novel pyrrole-based compounds as potential antituberculosis agents. [PDF]

J Comput Aided Mol Des
Ragno R, Zwergel C, Valente S, Astolfi R, Lambona C, Proia E, Giuliani L, Franzblau SG, Fioravanti R, Mai A.   +9 more
europepmc   +1 more source

NaviDiv: a web app for monitoring chemical diversity in generative molecular design.

Digit Discov
Azzouzi M, Worakul T, Corminboeuf C.
europepmc   +1 more source

Precision fragment addition: domain-specific DeepFrag2 models for smarter lead optimization.

Digit Discov
García-Jacas CR, Green H, Wierbowski SD, Durrant JD.   +3 more
europepmc   +1 more source