Results 231 to 240 of about 24,421,738 (314)
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
wiley +1 more source
Machine learning-driven generation and screening of potential ionic liquids for cellulose dissolution. [PDF]
Qu M+5 more
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
wiley +1 more source
Exploration of crystal chemical space using text-guided generative artificial intelligence. [PDF]
Park H, Onwuli A, Walsh A.
europepmc +1 more source
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Machine learning workflows beyond linear models in low-data regimes. [PDF]
Dalmau D, Sigman MS, Alegre-Requena JV.
europepmc +1 more source
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach+8 more
wiley +1 more source
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa. [PDF]
Kallergis G+5 more
europepmc +1 more source
Prediction of reproductive and developmental toxicity using an attention and gate augmented graph convolutional network. [PDF]
Lee SH+9 more
europepmc +1 more source
Heuristic optimization in classification atoms in molecules using GCN via uniform simulated annealing. [PDF]
Polowczyk A, Polowczyk A, Woźniak M.
europepmc +1 more source