Results 191 to 200 of about 1,516,599 (318)

Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis. [PDF]

Genet Epidemiol
Xue D, Blue EE, Sofer T, Hughes TM, Rotter JI, Post WS, Fohner AE.   +6 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Ensemble-based genomic prediction for maize flowering time improves prediction accuracy and reveals novel insights into trait genetic variation. [PDF]

G3 (Bethesda)
Tomura S, Powell O, Wilkinson MJ, Cooper M.   +3 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Pharmacogenomics and Epigenetic Regulation Transforming Pediatric Precision Therapeutics. [PDF]

J Pers Med
Satyam SM, Prabhakar S, Densil T, Mohammed HT, Kumari R, El-Tanani M, Rehman A, Kharoufeh A, Dalbah M, Eltrabishi MTZM.   +9 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Not Just a Matter of Space: Integrating Ecological Niche Modeling With Genotype-Environment Associations Suggests High Maladaptation Risks Under Climate Change for a Microendemic Malagasy Frog. [PDF]

Ecol Evol
Belluardo F, Di Febbraro M, Lobón-Rovira J, Oliveira Alves I, Rasoazanany M, Andreone F, Rosa GM, Giovacchini S, Mirone E, Singh Jamwal P, Afonso S, Innangi M, Sferra G, Trucchi E, Mondanaro A, Carotenuto F, Loy A, Crottini A.   +17 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bridging tradition and innovation: a review of computer simulations in plant breeding. [PDF]

Theor Appl Genet
Stich B, Van Inghelandt D, Wu PY.
europepmc   +1 more source