Integrating deep learning and pangenomics to recover missing heritability from wild structural variations. [PDF]
BMC GenomicsWang Y, Cai M, Ma Y, Tellier A, Wei K.
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
GENETIC SPECTRUM OF NOONAN SYNDROME IN PEDIATRIC POPULATION
Noonan syndrome (NS) is an autosomal dominant hereditary disorder with a prevalence of 1:1000 to 1:2500 live births. First described in 1963 by pediatric cardiologist Jacqueline Noonan, this syndrome is classified among RASopathies which arise from ...
Sarajlija, Adrijan +7 more
core
A hybrid mamba-transformer architecture fusing clinical and genetic features for gestational diabetes mellitus prediction. [PDF]
PLoS OneHuang J, Shi W, Lin L, Wei Z, Li Q.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Engineered platforms for melanogenesis research: Bridging synthetic biology, bioengineering, and biomimetics. [PDF]
Bioeng Transl MedAnika B +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Animal models of gut microbiota-male reproductive interactions: methodological assessment, translational bottlenecks, and optimization strategies. [PDF]
Front Endocrinol (Lausanne)Ma Y, Diao X, Wang Z.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Miocene Evolutionary History Shaped the Phylogeography of Willow Species (<i>Salix</i> L.) in the European Alps. [PDF]
Biology (Basel)Pittet L +3 more
europepmc +1 more source