Results 211 to 220 of about 1,458,211 (268)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium. [PDF]

Circ Heart Fail
Jordan E, Moscarello T, Khafagy H, Parker PK, Grover P, Weinmann S, Liu J, Nomo A, Barker N, Brown EE, Berthold A, Chowns J, Christian S, Ekwurtzel A, Fan J, Kisling M, Ma D, Miller EM, Sweeney J, Reys B, Robles N, Von Wald L, Flowers W, Hershberger GL, Abraham KG, Burke MA, Diamond J, Drazner MH, Ewald GA, Gottlieb SS, Haas G, Hofmeyer M, Huggins GS, Jimenez J, Judge DP, Katz S, Kawana M, Kransdorf EP, Martin CM, Minami E, Owens A, Shah P, Shenoy C, Shore S, Smart F, Stoller D, Tallaj J, Tang WHW, Wang J, Wilcox J, Hershberger RE.   +50 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Evaluation of Multi-Breed Genomic Prediction Models for Carcass and Reproductive Traits in Zebu Beef Cattle. [PDF]

Anim Genet
Gubiani G, Temp L, Londoño-Gil M, Teodoro M, Oliveira E, Aguilar I, Bermann M, Lourenco D, Pereira ASC, Baldi F.   +9 more
europepmc   +1 more source

The role of genetic distance in modulating intraspecific plant-soil interactions among a diverse assemblage of tropical tree species seedlings. [PDF]

Proc Biol Sci
Soria Penafiel RI, Zambrano K, Aulestia C, Rivas-Torres G, Karubian J, Van Bael SA.   +5 more
europepmc   +1 more source

Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts

Orešković T, Jin D, Trichia E, Aguilar-Ramirez D, Xu Y, Foguet C, Hubbard T, Turner M, Vergara-Lope A, Fernández-Chirino L, Gil L, Hill MR, Alegre-Díaz J, Berumen J, Lewington S, Emberson JR, Kuri-Morales P, Tapia-Conyer R, Torres JM, Inouye M.   +19 more
europepmc   +1 more source

GPC: An expressive and tractable deep generative model for genetic variation data. [PDF]

PLoS Genet
Anand P, Liu A, Dang M, Fu B, Wei X, Van den Broeck G, Sankararaman S.   +6 more
europepmc   +1 more source

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases. [PDF]

Clin Cardiol
Mohsen-Pour N, Esmaeili S, Feyzi A, Sharafi A, Maleki M, Kalayinia S.   +5 more
europepmc   +1 more source