Results 281 to 290 of about 25,171,962 (340)
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Genetic models of carcinogenesis
Human Pathology, 1983The major genetic models of carcinogenesis are critically reviewed to determine their validity and relevance for clinical and experimental oncologists. Of major concern are the "two-hit" theory of Knudson and the host resistance system of Matsunaga. These models may be used to explain the pathobiologic peculiarities of human neoplasms, particularly ...
Robert P. Bolande, Michel Vekemans
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Genetic Models in Pathogenesis
Annual Review of Genetics, 2004▪ Abstract To decipher the complexity of host-pathogen interactions the widest possible range of model hosts and of analytical methods is required. As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases.
Elizabeth Pradel, Jonathan J. Ewbank
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An introduction to genetic algorithms
, 1996From the Publisher: "This is the best general book on Genetic Algorithms written to date. It covers background, history, and motivation; it selects important, informative examples of applications and discusses the use of Genetic Algorithms in ...
Melanie Mitchell
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Issues in Mental Health Nursing, 1985
(1985). A Genetic Model of Anxiety. Issues in Mental Health Nursing: Vol. 7, No. 1-4, pp. 159-199.
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(1985). A Genetic Model of Anxiety. Issues in Mental Health Nursing: Vol. 7, No. 1-4, pp. 159-199.
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Genetic polymorphisms and additive genetic models
Behavior Genetics, 1985The degree of genetic dissimilarity between inbred strains or substrains of mice may be estimated from available data concerning biochemical and immunological polymorphisms. Dissimilarities between substrains are bimodally distributed, suggesting that both genetic drift and contamination are responsible for substrain differences.
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Models of Genetic Recombination
Annual Review of Microbiology, 1974It will be my intention to compare established and recently proposed models for . genetic recombination, with special attention to the separate component principles they contain and the function ofthese principles in the various models. As increasing attention has been paid to realistic details of DNA structure and enzymology, recombination models have
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Genetic models for CNS inflammation
Nature Medicine, 2001The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as ...
Owens, T, Wekerle, H, Antel, J
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Characteristics of genetic epidemiology and genetic models for vitiligo
Journal of the American Academy of Dermatology, 2004Vitiligo occurs with a frequency of 0.1% to 2% in various populations and is classified into several subtypes by its clinical presentation. Although genetic factors are thought to be involved in the cause of vitiligo, the genetic models for different phenotypes of vitiligo are unknown.Our purpose was to explore potential genetic models for different ...
Jin-Xian Li +11 more
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Genetic models of schizophrenia
Acta Psychiatrica Scandinavica, 1982Multiple threshold models of inheritance are applied to a large sample of Franz Kallmann's (1938) pedigree data on schizophrenia. Paranoid and nonparanoid subtypes are represented in the models at different thresholds on a continuum of genetic‐environmental liability. Single major locus and multifactorial‐polygenic inheritance are ruled out as modes of
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Adapting genetic regulatory models by genetic programming
Biosystems, 2004In this paper, we focus on the task of adapting genetic regulatory models based on gene expression data from microarrays. Our approach aims at automatic revision of qualitative regulatory models to improve their fit to expression data. We describe a type of regulatory model designed for this purpose, a method for predicting the quality of such models ...
Roger Eriksson, Björn Olsson
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