Results 281 to 290 of about 25,628,644 (319)

Genetic models of carcinogenesis

Human Pathology, 1983
The major genetic models of carcinogenesis are critically reviewed to determine their validity and relevance for clinical and experimental oncologists. Of major concern are the "two-hit" theory of Knudson and the host resistance system of Matsunaga. These models may be used to explain the pathobiologic peculiarities of human neoplasms, particularly ...
Robert P. Bolande, Michel Vekemans
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Genetic Models in Pathogenesis

Annual Review of Genetics, 2004
▪ Abstract  To decipher the complexity of host-pathogen interactions the widest possible range of model hosts and of analytical methods is required. As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases.
Elizabeth Pradel, Jonathan J. Ewbank
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A Genetic Model of Anxiety

Issues in Mental Health Nursing, 1985
(1985). A Genetic Model of Anxiety. Issues in Mental Health Nursing: Vol. 7, No. 1-4, pp. 159-199.
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Models of Genetic Recombination

Annual Review of Microbiology, 1974
It will be my intention to compare established and recently proposed models for . genetic recombination, with special attention to the separate component principles they contain and the function ofthese principles in the various models. As increasing attention has been paid to realistic details of DNA structure and enzymology, recombination models have
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A model in mitochondrial genetics

Mathematical Biosciences, 1977
Abstract The cytoplasmically inherited petite mutations of the yeast Saccharomyces cerevisiae result in its being unable to use oxygen because of the lack in the mitochondrial DNA rings of some genes which code for certain respiratory enzymes. A model is examined which predicts the probability of a normal colony arising from the mating of two petites.
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Genetic models for plant pathosystems

Mathematical Biosciences, 2002
Deterministic, discrete time, genetics models for a resistant plant host and a virulent pathogen are developed and analyzed. The original model was developed by Leonard in 1977 for a single gene with haploid pathogens and diploid hosts [Ann. N.Y. Acad. Sci. 287 (1977) 207].
Linda J. S. Allen, Jacob C. Kesinger
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Genetic polymorphisms and additive genetic models

Behavior Genetics, 1985
The degree of genetic dissimilarity between inbred strains or substrains of mice may be estimated from available data concerning biochemical and immunological polymorphisms. Dissimilarities between substrains are bimodally distributed, suggesting that both genetic drift and contamination are responsible for substrain differences.
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Genetic models of schizophrenia

Acta Psychiatrica Scandinavica, 1982
Multiple threshold models of inheritance are applied to a large sample of Franz Kallmann's (1938) pedigree data on schizophrenia. Paranoid and nonparanoid subtypes are represented in the models at different thresholds on a continuum of genetic‐environmental liability. Single major locus and multifactorial‐polygenic inheritance are ruled out as modes of
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Strategic and genetic models of evolution

Mathematical Biosciences, 1999
A new model which allows both for the effect of behavioural patterns on productive matings and for parental investment in the survival of offspring to maturity is considered. This combines ideas from genetics and evolutionary game theory, and provides a more realistic formulation to describe mating behaviour than the traditional 'battle of the sexes ...
Linda Rass, John Radcliffe
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Genetic models for CNS inflammation

Nature Medicine, 2001
The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as ...
Owens, T, Wekerle, H, Antel, J
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