Results 91 to 100 of about 27,132,286 (267)

Do we need to know the temperature in prestellar cores?

, 2007
Molecular line observations of starless (prestellar) cores combined with a chemical evolution modeling and radiative transfer calculations are a powerful tool to study the earliest stages of star formation. However, conclusions drawn from such a modeling
Henning, Th., Pavlyuchenkov, Ya., Wiebe, D.   +2 more
core   +1 more source

Epithelial–mesenchymal transition (EMT) and its role in acquired epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) chemoresistance in non-small cell lung cancer (NSCLC)

Cancer Pathogenesis and Therapy
Epithelial–mesenchymal transition (EMT) is a biological process that involves the transformation of epithelial cells into cells with a mesenchymal phenotype, enhancing their migratory and invasive capabilities.
Ma. Carmela P. Dela Cruz, Paul Mark B. Medina   +1 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Phenolic-rich lees from Philippine rice wine (tapuy) increases Caenorhabditis elegans lifespan in spite of having low antioxidant activity

Food Production, Processing and Nutrition
Tapuy is an indigenous wine produced in the Philippines. Rice wine fermentation produces a by-product of rice leftover and microbial biomass, collectively called lees, which usually is discarded as a waste product.
Sean Philippe L. Chua, Lesley Dale Umayat, Paul Mark B. Medina   +2 more
doaj   +1 more source

Skeletal dysmorphology and mineralization defects in Fgf20 KO mice

Frontiers in Endocrinology
IntroductionFibroblast growth factor 20 (Fgf20), a member of the Fgf9 subfamily, was identified as an important regulator of bone differentiation and homeostasis processes. However, the role of Fgf20 in bone physiology has not been approached yet.
Sylvie Dlugosova, Frantisek Spoutil, Carlos Eduardo Madureira Trufen, Betul Melike Ogan, Michaela Prochazkova, Olha Fedosieieva, Petr Nickl, Goretti Aranaz Novaliches, Radislav Sedlacek, Radislav Sedlacek, Jan Prochazka, Jan Prochazka   +11 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Coupling Lattice Boltzmann and Molecular Dynamics models for dense fluids

, 2006
We propose a hybrid model, coupling Lattice Boltzmann and Molecular Dynamics models, for the simulation of dense fluids. Time and length scales are decoupled by using an iterative Schwarz domain decomposition algorithm.
A. Dupuis, B. Chopard, B. F. Smith, E. M. Kotsalis, P. Koumoutsakos, S. Succi   +5 more
core   +2 more sources

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Non-Equilibrium Chemistry of Dynamically Evolving Prestellar Cores: I. Basic Magnetic and Non-Magnetic Models and Parameter Studies

, 2012
We combine dynamical and non-equilibrium chemical modeling of evolving prestellar molecular cloud cores, and explore the evolution of molecular abundances in the contracting core.
Tassis, Konstantinos, Turner, Neal J., Willacy, Karen, Yorke, Harold W.   +3 more
core   +1 more source