Results 101 to 110 of about 2,144,277 (316)

Novel Solubility Prediction Models: Molecular Fingerprints and Physicochemical Features vs Graph Convolutional Neural Networks. [PDF]

ACS Omega, 2022
Lee S, Lee M, Gyak KW, Kim SD, Kim MJ, Min K.   +5 more
europepmc   +1 more source

Modelling techniques for the study of molecular self-organisation [PDF]

, 2010
In this thesis we develop computational techniques for modelling molecular selforganisation. After a short review of the current nanotechnological applications of molecular self-assembly and the main problems encountered in modelling the selforganised
Fortuna, Sara
core  

Comparative Analysis of Mouse Decidualization Models at the Molecular Level

, 2020
The mouse is widely used to study decidualization and there are three well-established mouse models of decidualization, namely natural pregnancy decidualization (NPD), artificial decidualization (AD), and in vitro decidualization (IVD).
Can Zhu, Jia-Peng He, Chong Wang, Miao Zhao, Wen-Qian Zhang, Ming-Yu Huang, Ji-Long Liu   +6 more
core   +1 more source

Pathology of Mouse Models of Accelerated Aging [PDF]

, 2016
Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and humans.
de Bruin, A, Youssef, S A, Dutch Molecular Pathology Centre, Harkema, L., dPB RMSC, LS Pathobiologie, Regenerative Medicine, Stem Cells & Cancer, de Bruin, A., Harkema, L, Youssef, S. A.   +9 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Comprehensive evaluation and guidance of structural variation detection tools in chicken whole genome sequence data

BMC Genomics
Background Structural variations (SVs) are widespread across genome and have a great impact on evolution, disease, and phenotypic diversity. Despite the development of numerous bioinformatic tools, commonly referred to as SV callers, tailored for ...
Cheng Ma, Xian Shi, Xuzhen Li, Ya-Ping Zhang, Min-Sheng Peng   +4 more
doaj   +1 more source

Model Selection and the Molecular Clock

PLoS Biology, 2006
A brief overview of the methods used to determine phylogenetic distances sets the stage for understanding new research published in PLoS Biology.
openaire   +4 more sources

Genetic Mouse Models of Neurodegenerative Diseases

Neurodegenerative diseases are generally characterized by the selective degeneration of particular neuronal populations and the accumulation of abnormal or aggregated proteins within, but occasionally external to, neurons in affected brain regions. These
Moore, Darren J., Trancikova, Alzbeta, Ramonet, David   +2 more
core   +1 more source

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology [PDF]

, 2019
Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities.
Hiba El Hajj, Nadine Darwiche, Hleihel, Rita S., Maguy Hamieh, El-Hajj, Hiba Ahmad, Marwan El Sabban, Bazarbachi, Ali Abdul Hamid, El-Sabban, Marwan E., Rita Hleihel, Hamieh, Maguy, Jishi, Batoul, Ali Bazarbachi, Hala Skayneh, Batoul Jishi, Skayneh, Hala, Darwiche, Nadine D.   +15 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source