Results 231 to 240 of about 11,616,863 (296)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Task-adaptive multimodal molecular representations for structure-sensitive property prediction. [PDF]

Chem Sci
Lin S, Zhai S, Wang S, Zhan X, Li Y, Li W, Qin L, Shi L, Tian Y, Xu K, Zhou K, Gu C, Liu H, Yao X.   +13 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

LMF-CP: An Interpretable Multimodal Late-Fusion Framework for Compound Carcinogenicity Prediction. [PDF]

Int J Mol Sci
Zhu Y, He L, Liang X.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

PockLigGPT: Pocket-Sequence-Conditioned Molecular Generation with GPTs and RL. [PDF]

J Chem Inf Model
Varas Pardo P, Marcos-Ayuso G, Ulzurrun E, Ríos Insua D, Campillo NE.   +4 more
europepmc   +1 more source

A hybrid high activity aware framework integrating graph attention network and transformer for half maximal inhibitory concentration prediction. [PDF]

Front Immunol
Ban D, Pan L, Zhang X, Xu P, Wang B, Liu T, Pan D, Li X.   +7 more
europepmc   +1 more source

Prediction of Ocular Toxicity of Prostaglandin F_2α Analogs Based on Local Computational Models: Superiority over Global Models and Experimental Validation. [PDF]

Molecules
Lu X, Ren L, Wang C, Liao H, Liu L, Han M, He L, Zhang D, Fan H, Xu M.   +9 more
europepmc   +1 more source

Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis. [PDF]

Hum Brain Mapp
Pinamonti M, Moretto M, Sammassimo V, Castellaro M, Veronese M.   +4 more
europepmc   +1 more source

Artificial Intelligence and Multi-Omics Approaches in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification. [PDF]

Int J Mol Sci
Ferrantelli S, Del Cuore A, Cassataro G, Dell'Ajra L, Norrito R, Geraci G, Carmina G, Minà C, Polizzi V, Ciancio N, Maida CD.   +10 more
europepmc   +1 more source