Results 61 to 70 of about 3,509,714 (267)

Constant Size Molecular Descriptors For Use With Machine Learning

, 2017
A set of molecular descriptors whose length is independent of molecular size is developed for machine learning models that target thermodynamic and electronic properties of molecules. These features are evaluated by monitoring performance of kernel ridge
Carr S., Christopher R. Collins, David J. Yaron, Duvenaud D. K., Geoffrey J. Gordon, Koch W., Montavon G., O. Anatole von Lilienfeld, Pedregosa F., Wong E.   +9 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The Global Evolution of Giant Molecular Clouds II: The Role of Accretion [PDF]

, 2011
We present virial models for the global evolution of giant molecular clouds. Focusing on the presence of an accretion flow, and accounting for the amount of mass, momentum, and energy supplied by accretion and star formation feedback, we are able to ...
Abdo, Ballesteros-Paredes, Ballesteros-Paredes, Bigiel, Blitz, Bolatto, Christopher D. Matzner, Christopher F. McKee, Dickel, Engargiola, Evans, Fall, Fukui, Glover, Heiles, Heyer, Heyer, Heyer, Hughes, Imara, Kawamura, Kegel, Kennicutt, Kim, Kim, Kim, Krumholz, Krumholz, Krumholz, Krumholz, Krumholz, Krumholz, Lada, Larson, Leroy, Leroy, Li, Li, Li, Li, Lopez, Mark R. Krumholz, Matzner, Matzner, Matzner, McKee, McKee, McKee, Meynet, Mizuno, Murray, Nathan J. Goldbaum, Onodera, Parravano, Roman-Duval, Rosolowsky, Schaerer, Schlegel, Schruba, Schruba, Stark, Stone, Strong, Tamburro, Tan, Tan, Tasker, Tasker, Thilker, Troland, Vazquez-Semadeni, Vázquez-Semadeni, Wang, Wang, Williams, Wise, Wolfire, Wong, Wong, Yang   +79 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transport of Molecular Motor Dimers in Burnt-Bridge Models

, 2007
Dynamics of molecular motor dimers, consisting of rigidly bound particles that move along two parallel lattices and interact with underlying molecular tracks, is investigated theoretically by analyzing discrete-state stochastic continuous-time burnt ...
Alexander Yu Morozov, Anatoly B Kolomeisky, Artyomov M N, Bray D, Howard J, Lodish H   +5 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Global Collapses and Expansions in Star-Forming Clouds

, 2009
Spectral molecular line profile observations of star-forming molecular clouds sometimes show distinct red asymmetric double-peaked molecular line profiles with weaker blue peaks and stronger red peaks.
Adams, Adelson, Aguti, Arons, Belloche, Bernes, Bian, Carolan, Di Francesco, Evans, Fiege, Fiege, Fuller, Gao, Hammersley, Harvey, Hennebelle, Hogerheijde, Hu, Jørgensen, Kenyon, Keto, Lada, Larson, Lee, Lou, Lou, Lou, Lou, MacLow, Mardones, Matthews, Matzner, Matzner, McKee, Moraghan, Moriarty-Schieven, Myers, Myers, Nakano, Ossenkopf, Ostriker, Park, Park, Park, Rawlings, Redman, Redman, Saito, Schöier, Shang, Shen, Shirley, Shreider, Shu, Shu, Shu, Shu, Su, Tafalla, Tafalla, Tafalla, Thompson, Tsamis, van der Tak, Van Zadelhoff, Velusamy, Wang, Ward-Thompson, Wilner, Wu, Yang Gao, Yu, Yu, Yu-Qing Lou, Zhou, Zhou, Zweibel   +77 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Molecular Neurodegeneration
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation.
Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao   +4 more
doaj   +1 more source

Tumor Cellular and Microenvironmental Cues Controlling Invadopodia Formation

Frontiers in Cell and Developmental Biology, 2020
During the metastatic progression, invading cells might achieve degradation and subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature using invadopodia, F-actin-based and force-supporting protrusive membrane structures ...
Ilenia Masi, Valentina Caprara, Anna Bagnato, Laura Rosanò, Laura Rosanò   +4 more
doaj   +1 more source