Results 41 to 50 of about 2,144,277 (316)
Ultrasensitive gene regulation by positive feedback loops in nucleosome modification
Molecular Systems Biology, 2008 Eukaryotic transcription involves the synergistic interaction of many different proteins. However, the question remains how eukaryotic promoters achieve ultrasensitive or threshold responses to changes in the concentration or activity of a single ...
Kim Sneppen +2 more
doaj +1 more source
Quaternions in molecular modeling [PDF]
Journal of Molecular Graphics and Modelling, 2007 Quaternions are an important tool to describe the orientation of a molecule. This paper considers the use of quaternions in matching two conformations of a molecule, in interpolating rotations, in performing statistics on orientational data, in the random sampling of rotations, and in establishing grids in orientation space.
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa +8 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro +11 more
wiley +1 more source
Molecular Medicine, 2020 Background Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis.
Xuan Li +9 more
doaj +1 more source
Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models
, 2016 Atherosclerosis is characterized by intimal plaques of the arterial vessels that develop slowly and, in some cases, may undergo spontaneous rupture with subsequent heart attack or stroke.
Matteo Gramanzini +2 more
core +1 more source
Added predictive value of high-throughput molecular data to clinical data, and its validation [PDF]
, 2010 Hundreds of ''molecular signatures'' have been proposed in the literature to predict patient outcome in clinical settings from high-dimensional data, many of which eventually failed to get validated. Validation of such molecular research findings is thus
Sauerbrei, Willi, Boulesteix, Anne-Laure
core +1 more source
Giving Attention to Generative VAE Models for De Novo Molecular Design
, 2021 We explore the impact of adding attention to generative VAE models for molecular design. Four model types are compared: a simple recurrent VAE (RNN), a recurrent VAE with an added attention layer (RNNAttn), a transformer VAE (TransVAE) and
Jim, Pfaendtner +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source