Results 61 to 70 of about 1,931,218 (266)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Skeletal dysmorphology and mineralization defects in Fgf20 KO mice
Frontiers in EndocrinologyIntroductionFibroblast growth factor 20 (Fgf20), a member of the Fgf9 subfamily, was identified as an important regulator of bone differentiation and homeostasis processes. However, the role of Fgf20 in bone physiology has not been approached yet.
Sylvie Dlugosova +11 more
doaj +1 more source
Native or Non-Native Protein-Protein Docking Models? Molecular Dynamics to the Rescue. [PDF]
J Chem Theory Comput, 2021 Jandova Z, Vargiu AV, Bonvin AMJJ.
europepmc +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions. [PDF]
Pharmacol Rev, 2022 Golub VM, Reddy DS.
europepmc +1 more source
Molecular modelling of fentanyl analogs
Journal of the Serbian Chemical Society, 2004 Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight ...
openaire +3 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Journal of Pharmacy and Bioallied Sciences, 2009 <div>The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important</div><div>tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and</div><div>the exponential growth of the knowledge of protein structures have made it
Aarti Sharma, Himanshu Gupta
openaire +3 more sources
Protocol for in vivo analysis of muscle function in porcine models for muscular dystrophies
STAR ProtocolsSummary: Porcine models carrying DMD mutations recapitulate Duchenne and Becker muscular dystrophy (DMD and BMD), inherited disorders leading to progressive muscle weakness, with DMD presenting a far more severe and rapidly progressive phenotype ...
Hristiyan Hristov +10 more
doaj +1 more source
Novel Solubility Prediction Models: Molecular Fingerprints and Physicochemical Features vs Graph Convolutional Neural Networks. [PDF]
ACS Omega, 2022 Lee S +5 more
europepmc +1 more source