Results 61 to 70 of about 2,144,277 (316)
Tumor Cellular and Microenvironmental Cues Controlling Invadopodia Formation
Frontiers in Cell and Developmental Biology, 2020 During the metastatic progression, invading cells might achieve degradation and subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature using invadopodia, F-actin-based and force-supporting protrusive membrane structures ...
Ilenia Masi +4 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Hybrid molecular and continuum fluid dynamics models for micro and nanofluidic flows [PDF]
, 2009 From molecules to living organisms and from atoms to planets a variety of physical phe- nomena operate at different temporal and spatial scales. Understanding the nature of those phenomena is crucial for advancing new technologies in many disciplines ...
Asproulis, N.
core
Two main skeletal muscle molecular phenotypes of mouse dm1 models: a comparative transcriptomic analysis [PDF]
, 2023 Introduction:Myotonic dystrophy type 1 (DM1) is a rare, incurable multisystemic disease, with the main symptoms being skeletal muscle weakness, atrophy, and myotonia. It is caused by CTG expansion in the 3' UTR of the DMPK gene whose RNA acquires toxic
Savić-Pavićević, Dušanka +4 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Molecular mimicry between tumor associated antigens and microbiota-derived epitopes
Journal of Translational Medicine, 2022 Background The gut microbiota profile is unique for each individual and are composed by different bacteria species according to individual birth-to-infant transitions.
Concetta Ragone +7 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecular modelling of meso- and nanoscale dynamics [PDF]
, 2008 Molecular modelling of meso- and nanoscale dynamics is concerned with length and time scales that are in the transition zone from molecular to continuum models.
Kalweit, Marco
core
Leveraging molecular structure and bioactivity with chemical language models for drug design
, 2021 Generative chemical language models (CLMs) can be used for de novo molecular structure generation. These CLMs learn from the structural information of known molecules to generate new ones.
Gisbert, Schneider +3 more
core +1 more source