Results 31 to 40 of about 2,144,277 (316)

Molecular Models of Nanodiscs

Journal of Chemical Theory and Computation, 2015
Nanodiscs are discoloidal protein-lipid particles that self-assemble from a mixture of lipids and membrane scaffold proteins. They form a highly soluble membrane mimetic that closely resembles a native-like lipid environment, unlike micelles. Nanodiscs are widely used for experimental studies of membrane proteins.
Iwona, Siuda, D Peter, Tieleman
openaire   +2 more sources

Mechanistic explanations and models in molecular systems biology

, 2013
Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression.
Bruggeman, F.J.; id_orcid, Bruggeman, F.J., Boogerd, F.C., Richardson, R.C., Boogerd, F.C.; id_orcid   +4 more
core   +1 more source

Accurate and Transferable Reactive Molecular Dynamics Models from Constrained Density Functional Theory

, 2021
Chemical reactions constitute the central feature of many liquid, material, and biomolecular processes. Conventional molecular dynamics (MD) is inadequate for simulating chemical reactions given the fixed bonding topology of most force fields, while ...
Gregory A., Voth, Chenghan, Li
core   +1 more source

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety

Bio-Protocol, 2023
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern.
Ngoc Tung Tran, Mikhail Lebedin, Eric Danner, Ralf Kühn, Klaus Rajewsky, Van Trung Chu   +5 more
doaj   +1 more source

Tapuy lees attenuate amyloid-β toxicity and dopaminergic neurodegeneration more effectively than Tapuy wine in C. elegans models of Alzheimer’s and Parkinson’s disease

Discover Food
Tapuy is a traditional rice wine from the Philippines. We explored the potential of Tapuy wine and its fermentation by-product, lees, in reducing amyloid-beta toxicity in Alzheimer’s disease (AD) and dopaminergic neurodegeneration in Parkinson’s disease (
Mark Joseph R. Remucal, Junelle Rey C. Bacong, Paul Mark B. Medina   +2 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

Journal of Translational Medicine, 2023
Background Glioblastoma (GBM) is recognized as among the most aggressive forms of brain tumor. Patients typically present with a five-year survival rate of less than 6% with traditional surgery and chemoradiotherapy, which calls for novel immunotherapies
Shijie Wang, Wenwen Wei, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Xudong Zhao   +6 more
doaj   +1 more source

Molecular psychiatry of zebrafish

, 2014
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry.
Parker, M. O., Stewart, AM, Stewart, A. M., Stewart, A. M ., Ullmann, J. F. P., Norton, WHJ, Ullmann, JFP, Kalueff, A. V., Gerlai, R, Norton, W. H. J., Brennan, C. H., Gerlai, R., Brennan, CH, Parker, MO, Kalueff, AV   +14 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

The lees extracts of Philippine rice wine (Tapuy) protect transgenic Caenorhabditis elegans from glyphosate-induced neurotoxicity

Food Production, Processing and Nutrition
Tapuy is an indigenous rice wine traditionally prepared during rituals and ceremonies in the northern regions of the Philippines. Its fermentation by-product, the Tapuy lees, is nutrient-dense but is underutilized for human consumption.
Junelle Rey C. Bacong, Mark Joseph R. Remucal, Paul Mark B. Medina   +2 more
doaj   +1 more source