Results 11 to 20 of about 2,144,277 (316)

Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions

Scientific Reports, 2023
Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in multiple independent lineages ...
Frantisek Spoutil, Goretti Aranaz-Novaliches, Michaela Prochazkova, Tomas Wald, Vendula Novosadova, Petr Kasparek, Radim Osicka, Janne E. Reseland, Staale P. Lyngstadaas, Hanna Tiainen, Kristyna Bousova, Jiri Vondrasek, Radislav Sedlacek, Jan Prochazka   +13 more
doaj   +1 more source

Why Deep Models Often Cannot Beat Non-deep Counterparts on Molecular Property Prediction?

, 2023
Molecular property prediction (MPP) is a crucial task in the drug discovery pipeline, which has recently gained considerable attention thanks to advances in deep neural networks.
Stan Z., Li, Xiao, Zhu, Jun, Xia, Lecheng, Zhang   +3 more
core   +1 more source

Atomistic Models and Molecular Dynamics [PDF]

, 2006
Here we show how atomistic computer simulation can help experiment unravel the rich structuralcomplexity of oxide nanomaterials and, ultimately, aid the fabrication of nanomaterials withimproved, tuneable or indeed new properties.
Sayle, Thi X. T., D. C. Sayle, Sayle, D.C., Sayle, T.X.T., Sayle, Dean C., T. X. T. Sayle   +5 more
core   +1 more source

Molecular mimicry and cancer vaccine development

Molecular Cancer, 2023
Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Franco M. Buonaguro, Maria Lina Tornesello, Luigi Buonaguro   +6 more
doaj   +1 more source

Mechanical molecular models and haptic reasoning [PDF]

, 2014
The use of physical models of molecular structures as research tools has been central to the development of biochemistry and molecular biology. Intriguingly, it has received little attention from scholars of science.
mathieu.charbonneau1@gmail.com, Mathieu Charbonneau   +1 more
core   +1 more source

erikweiand/cg-hair-surface-models: Coarse-grained molecular models of the surface of hair

, 2022
LAMMPS input files and initial configurations for coarse-grained molecular dynamics models of the surface of ...
erikweiand
core   +1 more source

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

Cell Death Discovery, 2021
Essential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma.
Marta Di Martile, Stefania Garzoli, Manuela Sabatino, Elisabetta Valentini, Simona D’Aguanno, Rino Ragno, Donatella Del Bufalo   +6 more
doaj   +1 more source

Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the Zfp644 mimic human disease phenotype

Cell & Bioscience, 2019
Zinc finger 644 (Zfp644 in mouse, ZNF644 in human) gene is a transcription factor whose mutation S672G is considered a potential genetic factor of inherited high myopia.
Katarzyna I. Szczerkowska, Silvia Petrezselyova, Jiri Lindovsky, Marcela Palkova, Jan Dvorak, Peter Makovicky, Mingyan Fang, Chongyi Jiang, Lingyan Chen, Mingming Shi, Xiao Liu, Jianguo Zhang, Agnieszka Kubik-Zahorodna, Bjoern Schuster, Inken M. Beck, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek   +17 more
doaj   +1 more source

Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson’s disease

Pharmaceutical Biology, 2020
Context L-DOPA is the first-line drug for Parkinson’s disease (PD). However, chronic use can lead to dyskinesia. Caffeine, which is a known neuroprotectant, can potentially act as an adjunct to minimise adverse effects of L-DOPA.
Rafael Vincent M. Manalo, Paul Mark B. Medina   +1 more
doaj   +1 more source

Molecular Modeling on the Web [PDF]

BioTechniques, 2001
With the worldwide genomic sequencing efforts producing a steady stream of data, the sequences of tens of thousands of proteins can now be determined. Understanding protein function requires knowledge of protein structure. Information on the 3-D structure of a protein can provide insight to the protein’s interactions with other molecules; this ...
openaire   +3 more sources