Results 21 to 30 of about 1,979,179 (267)

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

Cell Death Discovery, 2021
Essential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma.
Marta Di Martile, Stefania Garzoli, Manuela Sabatino, Elisabetta Valentini, Simona D’Aguanno, Rino Ragno, Donatella Del Bufalo   +6 more
doaj   +1 more source

Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the Zfp644 mimic human disease phenotype

Cell & Bioscience, 2019
Zinc finger 644 (Zfp644 in mouse, ZNF644 in human) gene is a transcription factor whose mutation S672G is considered a potential genetic factor of inherited high myopia.
Katarzyna I. Szczerkowska, Silvia Petrezselyova, Jiri Lindovsky, Marcela Palkova, Jan Dvorak, Peter Makovicky, Mingyan Fang, Chongyi Jiang, Lingyan Chen, Mingming Shi, Xiao Liu, Jianguo Zhang, Agnieszka Kubik-Zahorodna, Bjoern Schuster, Inken M. Beck, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek   +17 more
doaj   +1 more source

Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson’s disease

Pharmaceutical Biology, 2020
Context L-DOPA is the first-line drug for Parkinson’s disease (PD). However, chronic use can lead to dyskinesia. Caffeine, which is a known neuroprotectant, can potentially act as an adjunct to minimise adverse effects of L-DOPA.
Rafael Vincent M. Manalo, Paul Mark B. Medina   +1 more
doaj   +1 more source

Molecular Modeling on the Web [PDF]

BioTechniques, 2001
With the worldwide genomic sequencing efforts producing a steady stream of data, the sequences of tens of thousands of proteins can now be determined. Understanding protein function requires knowledge of protein structure. Information on the 3-D structure of a protein can provide insight to the protein’s interactions with other molecules; this ...
openaire   +3 more sources

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness

Scientific Reports, 2017
Gastrulation initiates with the formation of the primitive streak, during which, cells of the epiblast delaminate to form the mesoderm and definitive endoderm.
Shohag Bhargava, Brian Cox, Christiana Polydorou, Veronika Gresakova, Vladimir Korinek, Hynek Strnad, Radislav Sedlacek, Trevor Allan Epp, Kallayanee Chawengsaksophak   +8 more
doaj   +1 more source

Chimeric Antigen Receptor T Cells Targeting Cell Surface GRP78 to Eradicate Acute Myeloid Leukemia

Frontiers in Cell and Developmental Biology, 2022
Acute myeloid leukemia (AML) is a serious, life-threatening hematological malignancy. The treatment outcome of relapsed or refractory AML patients remains dismal, and new treatment options are needed.
Wei Yu, Hang Zhang, Yuncang Yuan, Jie Tang, Xinchuan Chen, Ting Liu, Xudong Zhao   +6 more
doaj   +1 more source

Antigenic molecular mimicry in viral-mediated protection from cancer: the HIV case

Journal of Translational Medicine, 2022
Background People living with HIV/AIDS (PLWHA) show a reduced incidence for three cancer types, namely breast, prostate and colon cancers. In the present study, we assessed whether a molecular mimicry between HIV epitopes and tumor associated antigens ...
Carmen Manolio, Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Lina Tornesello, Franco M. Buonaguro, Angelo Salomone Megna, Giovanna D’Alessio, Roberta Penta, Maria Tagliamonte, Luigi Buonaguro   +10 more
doaj   +1 more source

Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Ube3a Gene

Cells, 2022
Angelman syndrome (AS) is a neurodevelopmental disorder caused by deficits in maternally inherited UBE3A. The disease is characterized by intellectual disability, impaired motor skills, and behavioral deficits, including increased anxiety and autism ...
Linn Amanda Syding, Agnieszka Kubik-Zahorodna, Petr Nickl, Vendula Novosadova, Jana Kopkanova, Petr Kasparek, Jan Prochazka, Radislav Sedlacek   +7 more
doaj   +1 more source

Molecular Models of Nanodiscs

Journal of Chemical Theory and Computation, 2015
Nanodiscs are discoloidal protein-lipid particles that self-assemble from a mixture of lipids and membrane scaffold proteins. They form a highly soluble membrane mimetic that closely resembles a native-like lipid environment, unlike micelles. Nanodiscs are widely used for experimental studies of membrane proteins.
Iwona, Siuda, D Peter, Tieleman
openaire   +2 more sources

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety

Bio-Protocol, 2023
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern.
Ngoc Tung Tran, Mikhail Lebedin, Eric Danner, Ralf Kühn, Klaus Rajewsky, Van Trung Chu   +5 more
doaj   +1 more source