Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Emergence of Non-Traditional Cooperative Structures: Public and Private Policy Issues [PDF]
This paper examines new agricultural cooperative organizational models from an ownership rights perspective. We argue that new cooperative organizational models differ in the way ownership rights are assigned to the economic agents tied contractually to ...
Chaddad, Fabio Ribas, Cook, Michael L.
core +1 more source
The organization as an information system: signposts for new investigations [PDF]
, 1999 This paper focuses on the question of how industry should adapt to today's information environment. It is proposed that businesses should look to long-standing organizations such as the church and government for an appropriate information model.
Barlow, HA, Burke, ME
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Collaborating for Gender Equity in Christian Education
, 2020 This essay addresses the importance of teachers promoting gender equity. It explores potential causes for gender discrimination in Christian institutions including double standards, unequal representation, organizational culture and similarity attraction.
Castellon, Adrienne R., Sowerby, Stacy
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
‘And if I don’t want to work like an artist...?’ How the study of artistic resistance enriches organizational studies [PDF]
, 2013 An increasing number of artists, from theatre makers to painters, critique recent aesthetic developments in organizational life.* One of their topics is the relation between work and freedom, as employees, like artists, are required to bring fully into ...
Biehl-Missal, B
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Exploring Linkages between Industrial Innovation and Public Policy: Challenges and Opportunities
Vikalpa, 2018 Rakesh Basant
doaj +1 more source
The Clustering of Organizational Innovation: Developing Governance Models for Vertical Integration [PDF]
This case explores a cluster of firms that emerged sharing a particular ownership structure. Typically, clusters are thought of as interrelated firms that produce similar products and services.
Burress, Molly J. +2 more
core +1 more source