Results 51 to 60 of about 128,362 (267)

Modelos Organizacionais das Bibliotecas Municipais de Lisboa

Páginas a&b, 2020
Organizational management requires sustained strategies to continuously achieve effective and efficient actions. Its implementation implies planning practices, ways of structuring key organizational elements and mechanisms for both monitoring and ...
Filipe Casimiro , Carlos Guardado da Silva , Maria Carla Proença   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organizational and training factors that promote team science: A qualitative analysis and application of theory to the National Institutes of Health’s BIRCWH career development program

Journal of Clinical and Translational Science, 2017
Introduction Research organizations face challenges in creating infrastructures that cultivates and sustains interdisciplinary team science.
Jeanne-Marie Guise, Susan Winter, Stephen M. Fiore, Judith G. Regensteiner, Joan Nagel   +4 more
doaj   +1 more source

Modern Organization Models as a Means for Realization of Innovative Processes Increasing the Ukrainian Economy Competitiveness

Studia Ekonomiczne i Regionalne, 2020
Subject and purpose of work: Ukraine’s dynamics by the competitiveness indicators shows the low macroeconomic status and insufficient innovative business climate, yet it doesn’t contradict the opportunities of economic growth.
Popadynets Nazariy, Skrypko Tetyana
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Innovation as a transversal Axis in Organizational Business Models

Revista Escuela de Administracion de Negocios, 2017
In the field of business and administration, innovation has turned to be a differentiating factor in the business models of organizations; for this reason, this article aims at showing a theoretical reflection about innovation in various business models,
Luis Fernando Landazury Villalba, Franklin Ferrer Manotas   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

PERFORMANCE IN ORGANIZATIONS IN A HUMAN RESOURCE PERSPECTIVE [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2017
In turbulent financial and economic present conditions a major challenge for the general management of organizations and in particular for the strategic human resources management is to establish a clear, coherent and consistent framework in terms of ...
LOGOFĂTU MONICA, ȘTEFĂNESCU CRISTIAN
doaj