Results 131 to 140 of about 11,697,554 (295)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The statistical model for parton distributions
, 2012 7 pages, 3 figures, Invited talk at XX International Workshop on "`Deep-Inelastic Scattering and related subjects"', University of Bonn, Germany, March 26-30 2012, presented by F.
Bourrely, Claude +2 more
openaire +3 more sources
Steam engine parts lists and descriptions, 2004
, 2004 Historic Steam Models Working Masterpieces in ...
Steam Models Co
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Statistical models: an overview [PDF]
British Journal of Surgery, 2016 Ranstam, J, Cook, J
openaire +3 more sources
Canonical foliations of statistical manifolds with statistical models
Information GeometryAbstract Constructing a realisation of a statistical manifold as a statistical model, i.e a manifold with dual connections with respect to a Fisher metric, is an important question in information geometry. While a positive answer to this problem was given by the work on Hong Van Lé [1], writing explicitly the ...
Gnandi, Emmanuel +2 more
openaire +1 more source
Engaging and motivating students with authentic statistical projects in a capstone unit
, 2015 Students preparing for professional statistical work can benefit from experience with real statistical problems presented by real clients and requiring them to engage with the complete problem-solving process without the usual cues of ‘textbook’ examples.
Bilgin, Ayse A. +2 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source