Results 41 to 50 of about 3,383,156 (274)

Statistical Modeling of Spatial Extremes [PDF]

open access: yesStatistical Science, 2012
The areal modeling of the extremes of a natural process such as rainfall or temperature is important in environmental statistics; for example, understanding extreme areal rainfall is crucial in flood protection. This article reviews recent progress in the statistical modeling of spatial extremes, starting with sketches of the necessary elements of ...
A. C. Davison   +2 more
openaire   +7 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Comparing estimates of climate change impacts from process-based and statistical crop models

open access: yesEnvironmental Research Letters, 2017
The potential impacts of climate change on crop productivity are of widespread interest to those concerned with addressing climate change and improving global food security.
David B Lobell, Senthold Asseng
doaj   +1 more source

Measuring the Quality of Multivariate Statistical Models

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2018
Assessing the quality of a statistical model is very important, since it is crucial for the utility of the modelling process’ outcome. There are many different ways of measuring statistical models quality.
Michał Trzęsiok
doaj   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

AUTOMATED CONSTRUCTION OF 3D STATISTICAL SHAPE MODELS

open access: yesImage Analysis and Stereology, 2011
Automated segmentation of medical images is a difficult task because of the complexity of anatomic structures, inter-patient variability, and imperfect image acquisition.
Tomaž Vrtovec   +4 more
doaj   +1 more source

A Statistical Model for Helices with Applications [PDF]

open access: yesBiometrics, 2018
Summary Motivated by a cutting edge problem related to the shape of -helices in proteins, we formulate a parametric statistical model, which incorporates the cylindrical nature of the helix. Our focus is to detect a “kink,” which is a drastic change in the axial direction of the helix.
Mardia, KV, Sriram, K, Deane, CM
openaire   +4 more sources

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy