Results 71 to 80 of about 6,283,315 (292)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Statistical analysis of factor models of high dimension
, 2012 This paper considers the maximum likelihood estimation of factor models of high dimension, where the number of variables (N) is comparable with or even greater than the number of observations (T). An inferential theory is developed. We establish not only
Bai, Jushan, Li, Kunpeng
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Frontiers in Marine ScienceEnvironmental DNA (eDNA) is a powerful technique for biological assessments and monitoring in aquatic environments. The accurate interpretation of the source of eDNA detected requires understanding of its spatial and temporal bound.
Tiago A. M. Silva +4 more
doaj +1 more source
Wastewater Quality Estimation through Spectrophotometry-Based Statistical Models
Sensors, 2020 Local administrations are increasingly demanding real-time continuous monitoring of pollution in the sanitation system to improve and optimize its operation, to comply with EU environmental policies and to reach European Green Deal targets.
Daniel Carreres-Prieto +3 more
doaj +1 more source
Entropy in Spin Foam Models: The Statistical Calculation
, 2010 Recently an idea for computing the entropy of black holes in the spin foam formalism has been introduced. Particularly complete calculations for the three dimensional euclidean BTZ black hole were done.
Carlip S +8 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2007 Many statistical models are algebraic in that they are defined in terms of polynomial constraints, or in terms of polynomial or rational parametrizations.
Drton, Mathias, Sullivant, Seth
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Comparing the Estimation Power of Machine Learning Models and Statistical Models in Predicting Profit Component Changes and Selecting the Optimal Model [PDF]
تحقیقات مالیObjectiveThe aim of predicting profit changes is to create awareness for investors, financial analysts, managers, stock market officials, creditors, and other users to judge the business unit, make decisions about buying or selling stocks, or granting or
Maryam Izadi +2 more
doaj +1 more source