Results 81 to 90 of about 6,283,315 (292)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Scaling of local interface width of statistical growth models

, 2004
We discuss the methods to calculate the roughness exponent alpha and the dynamic exponent z from the scaling properties of the local roughness, which is frequently used in the analysis of experimental data.
Aarão Reis, Anna Chame, Baggio, Barabási, Buceta, Chatraphorn, Costa, Das Sarma, Das Sarma, Das Sarma, Das Sarma, Edwards, F.D.A. Aarão Reis, Family, Forrest, Horowitz, Huang, Kardar, Kim, Kotrla, Kotrla, Krim, Krug, Lai, Leschhorn, López, Majaniemi, Park, Plischke, Predota, Punyindu, Rao, Ryu, Siegert, Smilauer, Villain, Vvedensky, Wolf   +37 more
core   +1 more source

Asymmetric autoregressive models: statistical aspects and a financial application under COVID-19 pandemic. [PDF]

J Appl Stat, 2022
Liu Y, Mao C, Leiva V, Liu S, Silva Neto WA.   +4 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modeling Time-to-Acceptance for ISI-Indexed Journals in the Profession of Library and Information Science

International Journal of Librarianship, 2017
There are many factors affecting review duration after a paper has been submitted to a journal. Developing a time-to-acceptance model of each journal for the whole time span from submission to acceptance can help researchers when they are selecting ...
Jingjing Wu, Le Yang
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Thomas-Fermi Statistical Models of Finite Quark Matter

, 2009
I introduce and discuss models of finite quark matter using the formalism of the Thomas-Fermi statistical model. Similar to bag models, a vacuum energy term is introduced to model long distance confinement, but the model produces bound states from the ...
Abbasi, Alford, Alford, Alford, Alford, Alford, Berger, Choi, Dixon, Dixon, Farhi, Fermi, Kiriyama, Kiriyama, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Monreal, Nakano, Rajagopal, Rajagopal, Sikivie, Spence, Spruch, Thomas, Walter Wilcox, Weber, Witten   +32 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source