Results 101 to 110 of about 3,006,601 (299)

SHAPE - Statistical Models For Human Perception And Evaluation

open access: yes, 2014
The main aim of the Scientific project was to unify several approaches for modelling ordinal data by exploiting disseminated competences on alternative methodologies and performing an international experience on well documented data sets of real ...
M. Iannario
core  

Statistical Inference in Calibrated Models [PDF]

open access: yesJournal of Applied Econometrics, 1994
SUMMARY This paper describes a Monte Carlo procedure to assess the performance of calibrated dynamic general equilibrium models. The procedure formalizes the choice of parameters and the evaluation of the model and provides an efficient way to conduct a sensitivity analysis for perturbations of the parameters within a reasonable range.
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Modeling Time-to-Acceptance for ISI-Indexed Journals in the Profession of Library and Information Science

open access: yesInternational Journal of Librarianship, 2017
There are many factors affecting review duration after a paper has been submitted to a journal. Developing a time-to-acceptance model of each journal for the whole time span from submission to acceptance can help researchers when they are selecting ...
Jingjing Wu, Le Yang
doaj   +1 more source

Evaluating statistical information retrieval models with different indexing enhancement strategies

open access: yes, 2018
In this paper we will introduce the indexing enhancement for the Statistical Information Retrieval models (IR). To accomplish this task, we propose including an extra level of synonym and semantic classification and the distribution entropy of these ...
Matawie, Kenan M. (R8147), Hasso, Sargon
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Statistical Modeling of Spatial Extremes

open access: yesStatistical Science, 2012
The areal modeling of the extremes of a natural process such as rainfall or temperature is important in environmental statistics; for example, understanding extreme areal rainfall is crucial in flood protection. This article reviews recent progress in the statistical modeling of spatial extremes, starting with sketches of the necessary elements of ...
A. C. Davison   +2 more
openaire   +6 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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