Results 41 to 50 of about 4,232,997 (293)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Theoretical aspects of electroweak symmetry breaking in SUSY models

open access: yes, 2011
The electroweak (EW) symmetry breaking in the simplest supersymmetric (SUSY) extensions of the standard model (SM), i.e. minimal and next-to-minimal supersymmetric standard models (MSSM and NMSSM), is considered.
Nevzorov, R.
core   +1 more source

Theoretical models of planetary system formation: mass vs semi-major axis [PDF]

open access: yes, 2013
Planet formation models have been developed during the last years in order to try to reproduce the observations of both the solar system, and the extrasolar planets. Some of these models have partially succeeded, focussing however on massive planets, and
Alibert, Y.   +6 more
core   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Theory into Practice: An Overview of Historical Leadership Theories and Approaches

open access: yesEDIS
The Theory into Practice series is designed to outline a chronological perspective of leadership theories and approaches. Each article will highlight a theoretical perspective or leadership approach, a scenario in which the theory or approach can be or ...
Megan S. Cantrell
doaj   +3 more sources

Diseño de un modelo conceptual sobre la transferencia de resultados de investigación en salud pública en Honduras Design of a conceptual model on the transference of public health research results in Honduras

open access: yesSalud Pública de México, 2012
OBJETIVO: Diseñar un modelo conceptual sobre la comunicación de los resultados de la investigación científica en el área de la salud pública, en un contexto local.
César A Macías-Chapula
doaj  

Understanding with Theoretical Models [PDF]

open access: yesJournal of Economic Methodology, 2014
This paper discusses the epistemic import of highly abstract and simplified theoretical models using Thomas Schelling’s checkerboard model as an example. We argue that the epistemic contribution of theoretical models can be better understood in the context of a cluster of models relevant to the explanatory task at hand.
Aydinonat, N. Emrah, Ylikoski, Petri
openaire   +4 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Some theoretical results on neural spike train probability models

open access: yes, 2007
This article contains two main theoretical results on neural spike train models. The first assumes that the spike train is modeled as a counting or point process on the real line where the conditional intensity function is a product of a free firing rate
Chan, Hock Peng, Loh, Wei-Liem
core   +2 more sources

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